Barely Significant

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There was an overall trend for an interaction of sex and generation (‘Sex*Generation’: F 2,794 = 2.761, p = 0.064) that did not reach statistical significance, and we did not detect any effect of sex or the interaction between line and sex on the time individuals spent leading.
showed a trendp = 0.0641.3× alpha
At 105dpc, IGF1 levels showed a trend toward higher concentrations in conventional husbandry compared to the eco system (154.7 ng/ml (IQR 59.3–288.4) vs. 72.3 ng/ml (IQR 59.2–123.0), p = 0.064); however, this difference was no longer evident at 8dpp (222.7 ng/ml (IQR 189.0 −325.2) vs. 222.8 ng/ml (IQR 149.4–265.8), p = 0.779).
approached significancep = 0.0641.3× alpha
While differences in self-reported answers from the presence questionnaire were not significant (realism: t(21.2) = 0.20, p = 0.841, HMD-VR: M = 29.83 ± 8.2, CT: M = 29.08 ± 9.9; possibility to act: t(20.3) = 0.57, p = 0.573, HMD-VR: M = 19.0 ± 4.2, CT: M = 17.83 ± 5.7; possibility to examine: t(19.2) = −1.14, p = 0.269, HMD-VR: M = 11.5 ± 3.1, CT: M = 13.33 ± 4.6; self evaluation of performance: t(21.9) = 0.55, p = 0.586, HMD-VR: M = 9.42 ± 2.2; CT: M = 8.9 ± 2.3), questions addressing the quality of interface approached significance (quality of interface: t(21.2) = 1.95, p = 0.064, HMD-VR: M = 12.92 ± 2.7; CT: M = 10.5 ± 3.3), suggesting that participants in the HMD-VR and CT groups may have felt differences in the HMD-VR versus CT interfaces.
A greater proportion of patients in the historical cohort (15.4%, n = 25) were commenced on supplemental therapy of any description compared with the app-assisted group (8.92%, n = 15) however this did not quite reach statistical significance ( p = 0.064).