“marginal significance”

Also, ribo-lincRNAs generally exhibited higher GC-content than nonribo-lincRNAs (Mann–Whitney U test, P -value < 0.05; Figure 1H ), except for the BJ and RPE, with marginal significance for the hES and PC3, although lincRNAs typically had lower GC-content than protein-coding genes (Mann–Whitney U test, P -value < 3.5e-11; Supplementary Figure S8B and Table S7 ).

Marginal significance was observed at 19q13.11 (index by rs1345417: p = 1.42 × 10 − 7 ) and 20q12.1 (index by rs12651896: p = 1.81 × 10 − 7 , Figure S1D−F ).

Two SNPs on chromosome 5 and eight other SNPs on chromosome 12 were also associated with CIPN at a marginal significance level of p < 1.0 × 10 −6 .

However, this may be due to a difference in the linkage phase between the imputed alleles and causal mutations in each of the breeds, as the marginal significance of SNP ( P > 1 × 10 −6 ) just upstream of this QTL in the CH and LM populations does suggest that a QTL extending from the 57.9 to 58.2 Mb on BTA18 influences DCD in multiple breeds, albeit to a different extent.

A single SNP (rs4236644) in SEMA3C reached marginal significance ( p = 2e–6) in a meta-analysis of GWAS for total serum bilirubin levels ( Johnson et al. 2009 ).

The genome-wide analysis of TNE with CPD exhibited reduced marginal significance ( p -values < 3.4E-6), reduced numbers of variants in the chr15q25.1 and chr19q13.2 regions, and a different region with the most variants selected (chr10q25.3).

Variants in locus 6q24.3-q25.1 reached marginal significance (rs9390543, SASH1 , P = 3.56 × 10 –6 , OR 0.75) in CCSS and significance when meta-analyzing with SJLIFE ( P = 2.02 × 10 –8 , OR 0.75).

Genome-wide significance was the accepted P < 5 × 10 −8 while marginal significance was P < 1 × 10 −5 .

Correlation of CDX2 with clinicopathological parameters CDX2 expression was inversely associated with lymph node metastasis (high CDX2 expression was associated with decreased lymph node metastasis (RR=1.52, 95% CI: 1.29-1.79, P<0.00001) ( Figure 5 ) however, CDX2 expression was significantly higher in poorly differentiated gastric cancers (RR=1.52, 1.52; and significantly higher in well-differentiated and latent gastric cancers marginal significance compared with 95% CI: 1.22-1.87, P<0.00001) ( Figure 6 ) was observed (RR =0.82, 95%).CI =0.67-1.01, P=0.07) ( Figure 8 ).

Furthermore, a similar association pattern was observed in SNPs near the MIR4458HG gene (distance ~33 kb) in chromosome 5 with marginal significance ( P -value < 1.0E−05) in all models (Table 2 , Additional File 1 : Table S1).

Four SNPs showed associations with post-RT pain at the marginal significance level of p < 1 × 10 −5 ; rs16970540 in ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ( RFFL) or near to DNA ligase 3 ( LIG3 ) gene ( p = 1.7 × 10 −6 ), rs4584690, and rs7335912 in ATP-binding cassette, sub-family A, member 4 ( ABCC4)/ multidrug resistance protein 4 (MRP4) gene ( p = 5.5 × 10 −6 and p = 7.8 × 10 −6 , respectively), and rs73633565 in epidermal growth factor-like protein 6 ( EGFL6 ) gene ( p = 8.1 × 10 −6 ).

Of note, eleven of the 16 novel GWS loci exhibited consistent genome-wide marginal significance ( P < 5 × 10 −5 ) between ADHD and MDD.

In contrast, a previous meta-analysis of GWAS with a comparable sample size (∼ 30,000) reported that SNP rs1831554 within this locus showed marginal significance for femoral neck BMD ( P = 9.94 × 10 −5 ) and lumbar spine BMD ( P = 1.41 × 10 −4 ) [ 8 ].

To define a locus associated with increased adiposity and protective effects on cardiometabolic traits, we retained only variants for which the single-trait GWASs for both traits reached marginal significance, defined as P < 10 −4 , and for which the association was opposite to the established phenotypic correlation.

Any regional overlap (within 20 kb) of EWAS and GWAS signals of at least marginal significance (defined as P <1.0*10 −4 ) was identified.

To determine statistical significance, we used a two-tier thresholding strategy: a genome-wide marginal significance threshold of p ≤ 1.0 × 10 −4 (uncorrected), and a Bonferroni-corrected significance threshold computed based on the number of SNPs analyzed within each linkage-defined region.

Further, statistical significance was observed in the STAI; state anxiety levels were significantly higher in ARFID patients compared to the HC group, while trait anxiety showed only marginal significance (STAI State: U = 46, p = 0.00024, δ = −0.72; STAI Trait: U = 100, p = 0.051, δ = −0.38) (see Fig.

Although significant and marginal significance intergroup differences in P300 amplitude were identified [PBD versus SCZ: t (300) = 3.42, P = 0.0004; PBD versus SAD: t (252) = 1.79, P = 0.03; SCZ versus SAD: t (244) = −1.24, P = 0.11; fig.

Except for one SNP (intron ENSSSCG00000044652:g.8526 T>C (12:55,530,321)) showing marginal significance for C18:1 ( p = 0.0004), no additional significant association signals were detected ( Table 3 , Table 4 and Table 5 ).

After multiple comparison adjustment, miR-519a-3p remained significantly correlated with VO 2 peak ( P = .0001, FDR = 0.046, and r = 0.5) and miR-18a-3p showed marginal significance and correlation ( P = .0004, FDR = 0.092, and r = 0.4).

Five of these metabolites remained significant after Bonferroni correction including threonine ( P = 1.78 × 10 −4 ), talose ( P = 9.01 × 10 −5 ), lyxose ( P = 4.26 × 10 −5 ), methylmalonic acid ( P = 2.37 × 10 −5 ), and malonic acid ( P = 1.24 × 10 −5 ), and one with marginal significance (galactose, P = 5.71 × 10 −4 ).

Formal statistical significance was taken as p < 0.00067 and marginal significance 0.01 > p ≥ 0.00067.

In our study, rs41409056 in SLCO1B1 locus, showed marginal significance with p -value = 0.0007376.

We found no significant protein biomarkers in stage II, although there were two antibodies (YAP_pS127 and STAT5-alpha) with marginal significance (nominal p = 7.5×10 −4 and p adjust = 0.083 for YAP_pS127; nominal p = 8.9×10 −4 and p adjust = 0.083 for STAT5-alpha).

We used traditional levels of statistical significance throughout: 0.01 ≤ p -value < 0.05 indicated marginal significance, 0.001 ≤ p = value < 0.01 indicated significance, and p -value < 0.001 indicated high significance.