“showed a trend”

Study 2 showed a trend toward decreased impact (1 to 10: β = −0.42, P = 0.00, P adj . = 0.051), but no significant effect was found in Study 3 (1 to 10: β = 0.11, P = 0.45, P adj . = 0.67).

The smoothed spline model showed a trend of increasing and then decreasing morbidity with increasing SDI, analysed as R = 0.582, p = 0.000.

Patients with mutations in the LRP2 , DAXX , and PKN1 gene showed a trend of well‐differentiated and early‐stage tumors with less metastasis ( p = 0.000).

3 B and D) showed a trend of gradually transforming from multimodal to bimodal (core–satellite mode) — the “middle sector” of species with P = 30–70% gradually disappeared from the communities.

hepatica infection, IL10, showed a trend of activation with z-score of 0.423 (overlap p-value = 3.84E-16).

And activated CD8 + T cells showed a trend of negative association with riskscore ( p = 4.3e-12, r = − 0.24) (Fig. 5 L).

In the meta-analysis, one SNP, rs3987 at 4q26, reached GWAS significant p-value (p = 4.02×10 −8 ), and one SNP pair, rs1100508 CG and rs8111948 AA, showed a trend for two-locus association (p = 4.35×10 −11 ).

Surprisingly, results corresponding to the HELPO2 family showed a trend that did not fit with a normal distribution (W = 0.727, P = 5.135 e − 10 , Fig. 1B ).

When using lifetime smoking index as exposure, the results showed a trend similar to that of the smoking initiation analysis (OR, 1.49; 95% CI, 1.31–1.70; P = 2.5 × 10 −9 ; I 2 = 37%) ( Figure 3 and Supporting Information, Figure S1 ).

Conversely, the high-risk group showed a trend of resistance to some epigenetic drugs such as LAQ824 (a histone deacetylase inhibitor) ( r = -0.272, P = 4.15 × 10−8, Cohen’s d = -0.525).

However, two variants on chromosome 17 showed a trend toward significance in the Sierra Leone cohort (Table 1 and Extended Data Fig. 2e ). rs73397758 ( P = 5.5 × 10 −8 , odds ratio (OR) = 9.16) is ~350 KB (kilobase pairs) downstream of the gene CASC17 , a long non-coding RNA named for a genetic association with prostate cancer 37 , and 570 KB upstream

Specifically, target genes of miR-30a-5p, miR-486-5p, miR-30c-2-5p, miR-205-5p, and miR-106b-3p whose expression levels showed a trend from healthy controls to MIBC patients displayed an over-representation in several KEGG pathways such as “Pathways in cancer_Homo sapiens” (hsa05200; adj p = 1.05 × 10 –7 ), “MicroRNAs in cancer_Homo sapiens” (hsa05206; adj p = 2.97 × 10 –7 ) and “Bladder cancer_Homo sapiens” (hsa05219; adj p = 3.38 × 10 –5 ).

In contrast, rs187522732, located in the intergenic region between KCNJ3 and NR4A2 , showed a trend toward a significant association (effect size = 0.0713 [SE = 0.0145], P = 9.2 × 10 −7 ) in the discovery phase, but not in the replication phase ( P = 0.51).The combined P value for this variant in the meta-analysis ( P = 8.2 × 10 −6 ) was higher than that in the discovery phase, indicating that this association is likely a false positive.

2, Supplemental digital content 3, http://links.lww.com/FPC/B116 for Manhattan and quantile–quantile plots for the total PANSS score, the positive Marder factor score, the negative Marder factor score, and CGI-S, respectively) and 20+ regions including aarF domain containing kinase 1 ( ADCK1 ) that showed a trend toward association ( P <1.0×10 −6 ).

The body mass loss on Days 3 and 7 ( Figure 2 C) was significant in both MCAO groups, and on Day 14, it was significant in the MCAO-LM group and showed a trend in the MCAO-KM animals (ANOVA: F(1,36) = 35.13, p = 0.000001), but it did not depend on the model either (ANOVA: F(1,36) = 0.104 p = 0.74; MCAO-KM vs.

African (OR, 28.7; 95% CI, 0.6–300.6; P = 4.3 × 10 −2 ) and South Asian (OR, 32.4; 95% CI, 4.5–362.0; P = 1.7 × 10 −4 ) ancestry groups showed a trend toward enrichment that did not exceed study-wide significance ( P < 2.63 × 10 −6 accounting for ∼19,000 genes).

For SNPs that reached statistical significance ( P = 5.0×10 −8 /3 = 1.67×10 −8 , to account for three main tests) or showed a trend towards that threshold ( P < 5×10 −6 ), we performed stratified G×E analyses by sex, tumor site (proximal colon, distal colon, rectum), and study design.

Kaplan-Meier analysis showed a trend for significantly shorter MST with increasing number of risk alleles for the OS in patients with HBV-related HCC (Log-rank P = 7.72×10 −6 ; Figure 2 ).

No polymorphisms with genome-wide levels of significance (P<5*10(-7)) were identified, although rs740363 showed a trend for association with HF(P=8.8*10(-6)) [ 5 ].

Use of rtCGM showed a trend towards a larger effect (MD −3.95 mmol/mol [−0.36%]; 95% CI −5.46 to −2.44, p <0.00001, I 2 =0%) than use of isCGM (MD −1.79 mmol/mol [−0.16%]; 95% CI −5.28, 1.69, p =0.31, I 2 =64%).

Twelve novel loci showed a trend of association with V̇O 2 peak response that reached suggestive significance ( P < 1 × 10 –5 ).

Age showed a trend for association with individuals with both diseases (p = 0.00001; OR = 3.6, 95% C.I. 0.9-10.7) and chronic periodontitis alone (p = 0.002; OR = 3.0; 95% C.I. 0.8-10.52), suggesting that the difference in the distribution of BRINP3 alleles between healthy and individuals affected by peri-implantitis is confounded by the difference in the age of both groups (healthy individuals were on average 8 years younger than the affected individuals; Table 1 ).

In subsequent logistic regression analyses, 31 SNPs located in seven different genetic regions, including the MHC, showed a trend for association to OCB status (p<10 −5 ) ( Table S1 ).

In this analysis too, rtCGM showed a trend towards a larger effect (MD −3.95 mmol/mol [−0.36%]; 95% CI: −5.46 to −2.44, p < 0.00001) than isCGM (MD −1.79 mmol/mol [−0.16%]; 95% CI: −5.28, 1.69, p = 0.31).

Subgroup analysis of six studies with higher cumulative dose of statin use, defined as statin use over 180 cumulative defined daily doses (cDDDs) or 0.5 years (cumulative duration), showed a trend towards more risk reduction of liver cancer (RR=0.53, 0.36 to 0.79), but with a high degree of heterogeneity (I 2 =90%, p<0.00001; see online supplementary figure S7).