“marginally significant”

Effect of cilostazol on dementia risk Regarding the risk of dementia, cilostazol users had a marginally significant lower risk of dementia compared to the control group (pooled OR 0.90; 95% CI, 0.87 to 0.92; P = .000, I 2 = 40.7%) (Fig. 4 ).

In the first month, the difference in PCS scores between group A and group C was marginally significant ( p = 0, 08).

A post hoc Bonferroni test showed that the clinical group had significantly higher costs than the low and moderate group and the difference in costs between the clinical and borderline group was marginally significant, with the clinical group being more costly (post hoc Bonferroni: clinical versus low and moderate group: p = .00).

In the full cohort of HCC patients, preoperative CTC ≥ 2 had marginally significant association with increased tumor number (P = 0.067) and higher Edmonson grade (P = 0.064), while it had highly significant association with increased tumor size (P = 0.000), presence of PVTT (P = 0.000), and consequently higher BCLC stage (P = 0.000).

Fraction Csp3 showed highly significant correlations with Molar Refractivity (p = 1.7613E-37), MolVol (A3) (p = 4.2254E-26), and Druglikeness score (p = 9.35371E-33), while exhibiting marginally significant associations with TPSA(Å 2 ) (p = 0.059100432) and MolPSA (A2) (p = 0.055785406).

Here, over all animal groups, ∆f% had a marginally significant effect on the ENV/TFS log-z-ratio [main effect: F(1,943) = 4.278, p =0.039] and stimulus condition had a highly significant effect on the ENV/TFS log-z-ratio [main effect: F(2,943) = 43.929, p =5.744 × 10 –19 ].

Specifically, adjusting for African ancestry in a multiple regression model largely eliminated the highly significant effect of Black ethnicity on serum creatinine levels (decreased from P<2x10 -16 to a marginally significant P=0.05) whilst the highly significant effect of African ancestry on creatinine remained essentially unchanged when adjusted for Black ethnicity (P<2x10 -16 before and after adjustment).

Interestingly, we found a highly significant overlap between genes repressed in daGAL4 > UAS-dInR DN and those activated upon removal of dfoxo in that genetic context ( P <10 −15 ), while the overlap between genes activated in daGAL4 > UAS-dInR DN and repressed upon dfoxo deletion was marginally significant ( P =0.01).

For PLINK, a single SNP was deemed marginally significant if it belonged to a epistatic pair with a p-value below the genome-wide threshold P = 1.09 × 10 −10 (i.e.

One‐way ANOVA indicated that site ID was a highly significant predictor of diversity variation among samples for the Chao1 index ( F 12,75 = 7.66, p = 4.75 × 10 −9 ), and a marginally significant predictor for the Shannon index ( F 12,75 = 1.87, p = 005).

The same markers at MITF on CFA20 and USH2A on CFA38 were detected as marginally significant when both herding and non-herding breeds were analyzed together ( P = 3.5 x 10 −8 and P = 3.6 x 10 −8 , respectively).

Despite a large gap between variance explained by GWAS and the total variance of the trait, it has been shown that marginally significant SNPs that do not reach genome-wide significance ( P < 5 × 10 −8 ) contribute to the explained variance in the trait [ 24 ].

At 105 of 152 evaluated regions the main signal demonstrated genome-wide significance, while 44 were marginally significant (9.89×10 -5 ≥ p-value > 5×10 -8 ).

In addition, a region on chromosome 17 showed a marginally significant signal led by a marker on the GOSR2 gene (chr17:44967530–45244074, lead variant: chr17:45013271_T_C; minor allele frequency, 15%; β=7.83; SE=1.44; P =5.6×10 −8 ).

Meta-analysis of two independent Japanese datasets demonstrated a marginally significant association of SNP rs7301743 in TBX3|MED13L with a 0.071 mV (95% CI, 0.038–0.11 mV) shorter R wave amplitude in the V5 lead per minor allele copy (P = 7.635 x 10 −8 ).

rs1456315 was found to be marginally significant in the African American GWAS ( P = 1.29 × 10 −7 ). rs1456315 and rs72725879 are linked ( r 2 = 0.815) in the Japanese American GWAS population and have similar allele frequencies across East Asian populations while rs1456315 and rs72725879 are less linked ( r 2 = 0.448) in the African American GWAS population and have divergent allele frequencies across African populations ( Fig 2 ). r 2 values between SNPs were calculated using PLINK in each individual case-control study.

For example, the GC rs2282679 showed a marginally significant association in the QBB cohort ( p value = 2.61 × 10 −07 ) but had a significant association in the United Kingdom Biobank cohort ( p value = 1.0 × 10 −1,268 ).

Interestingly, among the top 25 associations detected, novel genome-wide marginally significant signals outside chromosome 19 were observed: in chromosome 12 (intergenic: rs249153, p = 4.38×10 −07 , OR = 1.41; intergenic: rs249166 and rs249167, both with p = 6.91×10 −07 and OR = 1.40) and in chromosome 5 (intergenic: rs13178362, p = 6.60×10 −07 , OR = 0.75), followed by trends inside the memb

Eight additional gene-gene interactions were also marginally significant ( P < 5 × 10 –7 ).

In addition, rs3831470 ( NADSYN1 ) showed marginally significant association in the mega-analysis ( P =9.68×10 −7 ) and significant association in the meta-analysis ( P =2.6×10 −9 ) ( Table 2 , Supplemental Fig.

An additional 79 variants were marginally significant ( p < 1.00E-06) and are described in Supplementary Table S3 .

This analysis points up 8 genes with a significant eQTL colocalization signal in ASD ( CRHR1, KANSL1, MANBA, MAPT, MMP12, NKX2-2, PTPRE and WNT3 ) and one gene ( SRPK2 ) with a marginally significant colocalization signal ( r = 0.69, p < 1 × 10 −6 ), and specifically highlights the potentially causal role of MAPT ( r = 0.76, p < 1 × 10 −6 ), NKX2-2 ( r = 0.71, p -value = 2.26 −02 ) and PTPRE ( r = 0.97, p -value = 2.63 −04 ) when restricting the analysis to brain tissue.

Based on the training data (and the additive model unless specified otherwise), we detected 1,758 marginally significant SNPs at p < 10 − 6 ; after removing those in high LD (i.e., correlation > 0.99 ), we had 1,652 SNPs.

Using the MLM method, we were only able to identify the marginally significant association for ZmCCT (−log 10 ( P ) = 5.64) and there were no strong signals in other genome regions ( Figure 2B ).

In addition, CpG06500161 was also significantly associated ( P = 1.60 × 10 −9 ) with HOMA-IR, while CpG1881899, also a CpG site in ABCG1 , was marginally significant for that phenotype ( P = 3.36 × 10 −6 ).