Excerpts

In contrast to 30 mg QD dacomitinib and 80 mg QD osimertinib, we observed a marginally significant improvement after 1 year of treatment ( P = 0.051) after multiple comparison corrections.

A borderline significance for cases with DUX4 rearrangements being older than cases lacking such fusions (Mann–Whitney's two-sided test, P =0.051; median age 6.5 versus 4 years) was seen in the discovery cohort.

At the same time, dHPC - neurons showed only a trend towards significance using t -statistics ( P = 0.051, Welch’s t -test; Fig. 4e, f ) that reached significance using estimation statistics (Supplementary Fig. 5p ).

Net flow also showed a significant overall effect across respiratory-like conditions (Kruskal–Wallis test, H = 5.69, p = 0.029), with condition 1 versus 3 approaching significance ( p = 0.051), indicating a trend toward enhanced net flow with stronger respiratory modulation.

This showed a trend towards a higher proportion of CD8 naive cells in both scRNA-seq and flow cytometry data ( P = 0.051 and P = 0.065), suggesting microenvironmental differences between the two NPM1 classes affecting the T cell composition already at diagnosis.

Within a constrained range (scaled V 3 < 0.8), time pressure exhibited a marginally significant interaction with contextual variance ( β = 0.46, s.e. = 0.23, t = 1.95, p = 0.051, standardized coefficient = 0.08, 95% C.I. = [0, .15]) — a pattern consistent with the model prediction of a flatter early noise effect under high time pressure due to early-late noise tradeoff.

However, unlike the univariate models, the full model revealed a borderline non-significant effect of breathing type at both the food web and top predator levels ( p = 0.051 and p = 0.057, respectively).

In correspondence with increased selfing, hoverfly-pollinated plants showed a trend towards reduction in pistil length ( Supplementary Table 2 ; P =0.051), and a significant decrease in the emission of the three scent compounds methyl salicylate, p -anisaldehyde and indole ( Table 1 ; Supplementary Table 2 and Fig. 4c ).

These 40 consensus modules were significantly related to cortisol stress reactivity in the discovery sample (multiple analysis of covariance (MANCOVA) Pillai's trace=0.72, F(40,37)=2.4, P =0.004) and borderline significant in the cross-tissue replication sample (MANCOVA Pillai's trace=0.21, F(40,212)=1.4, P =0.051).

However, we do point out interesting trends that approached significance in Fig. 1d ( p = 0.051), Fig. 3d ( p = 0.055), Fig. 5c ( p = 0.054), and Supplementary Fig. 10c ( p = 0.052).

While we observed a strong trend towards lower active β1-integrin in dy W / dy W PMs ( P = 0.0512) (Fig.

3d ), with a clear trend visible also for Oscillospiracaee ( P = 0.052).

To test if this preference for high calorie food differed between groups, a linear mixed effects model revealed a small, borderline non-significant main effect of calorie level (high vs. low) on stimulus value ratings ( β calorie level = 0.02 ± 0.01, t(506) = 1.95, p = 0.052, 95% CI [2.20e-4 to 0.05]) and a significant main effect of group ( β group = 0.09 ± 0.03, t(506) = 2.71, p < 0.001, 95% CI [0.02–0.15]).

Notably, PanK4 mKO mice had approximately 100% higher SkM glycogen levels than WT controls, with an overall trend ( p = 0.052) toward reduced glycogen levels following exercise (Fig S7I).

In addition, GATA3 significantly repressed ‘stem cell' genes whose downregulation is essential for further T cell development ( LMO2 , MEF2C and SPI1 ) 33 34 , and/or that are involved in the development of other haematopoietic lineages such as CD79A for B cell development (downregulation of EBF1 , expressed at low levels, was observed but just failed to reach significance, P =0.052) and ID2 for NK-lineage differentiation 35 ( Fig. 5e , Supplementary Data 1 ).

During the probe period, however, stronger face evidence scores were associated with more accurate responses to the face probe (20–24 s, P =0.013); a similar trend was present for the relative face–scene scores (that is, a negative trend for scene–face; P =0.052).

Unexpectedly, potted plants also had a greater increase in T leaf compared with free-rooted plants, albeit only marginally significant ( Q M = 3.77, p = 0.052; Fig. 5a ).

Next, focusing on PGC1.5 women only, a comparison to UKB showed significant genetic correlations with the overall UKB ( r g = 0.46, P = 0.0004) and UKB women ( r g = 0.46, P = 0.0008), and a slightly lower, but marginally significant correlation with the smaller UKB male data ( r g = 0.44, P = 0.052).

Moreover, the MYC/E2F Activation factor significantly increased post-treatment in all samples ( p = 6.9e-06, WRST) with a marginally significant increase among paired samples ( p = 0.052, paired WRST) (Supplementary Fig. 5c ).

In addition, we found a marginally significant increase in support for the outgroup (unlimited vs. control, p = 0.052; unlimited vs. limited, p = 0.075) and no significant difference in support for the ingroup (unlimited vs. control, p = 0.72; unlimited vs. limited, p = 0.42).

The longitudinal associations with MD of the cingulate part of the cingulum and superior corona radiata showed a trend in men ( p = 0.052 and 0.099, respectively), but were not significant in women ( p = 0.952 and 0.301, respectively).

5a ), but when we calculated multifunctionality as the average of thresholds, this relationship was only marginally significant (Pearson correlation; r = 0.63, p = 0.052, Fig. 5d ).

A 2x2 ANOVA revealed main effects of culture density (F(1, 35)=39.5; P <0.0001) and the interaction between density and species (F(1, 35)=23.2; P <0.0001), whereas the effect of species was only marginally significant (F(1, 35)=4.1; P =0.0521).

Chromosome 8 displayed borderline significance ( P = 0.0529; two-sided exact binomial test) for fewer cases with subclonal UPID/trisomy than expected (Supplementary Table 2 ), possibly indicating that some cases were gaining an extra chromosome from a disomy, in line with positive selection.

hsa-let-7d-3p was also included because its levels were elevated in sCJD blood, albeit with borderline significance (FC 1.94, adjusted p = 0.053).