Barely Significant

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marginally non-significantp = 0.0541.1× alpha
In the prespecified primary multivariable model, RF positivity was marginally non-significant (aOR 3.44, 95% CI 0.98–12.11, p = 0.054), but became significant in the PFT analysis, but became non-significant after adding dyspnea/Velcro crackles and in the matched analysis, suggesting that any RF signal was not solely explained by symptom-driven ascertainment.
a trend toward significancep = 0.0541.1× alpha
Diastolic blood pressure (DBP) also showed favorable trends, with a significant reduction in the combination therapy group (from 81.6 mmHg to 73.0 mmHg, p = 0.040), a trend toward significance in the SGLT2i group (from 76.0 mmHg to 73.3 mmHg, p = 0.054), and a non-significant reduction in the GLP-1 RA group (from 74.8 mmHg to 70.4 mmHg, p = 0.335).
marginal significancep = 0.0541.1× alphagold
In a fully saturated model simultaneously including sex, mechanical ventilation and comorbidity count (six predictors for 33 events, well beyond the events-per-variable limit), the AISI effect retained a comparable magnitude (aOR 2.57) but reached only marginal significance (95% CI 0.98–6.72, p = 0.054), an attenuation attributable to over-parameterization rather than to loss of signal, and one that underscores why the pre-specified parsimonious model was the appropriate primary specification.