Excerpts

Using Pearson’s χ 2 test, we found the difference to be highly significant ( p = 3.4 × 10 −16 ), possibly suggesting a selection against the G/G (CFA5 locus) T/T (FructoCFA3) genotype combination.

Third, the strong and highly significant correlation between the associated effects of 37 sex-shared VV lead variants in FinnGen common for UK Biobank and FinnGen data ( r = 0.92, P = 3.6 × 10 −16 ; Supplementary Fig. 1 ) implies a high concordance between the VV ascertainment for the two cohorts.

A logistic regression was used to check whether more Achilles-based essentiality cases are predicted to be essential by our algorithm than Achilles-based non-essentiality ones, and the results are highly significant ( p -value = 3.78×10 −16 , odds ratio (OR) = 3.62) (see “Methods” section).

hepatica infection, IL10, showed a trend of activation with z-score of 0.423 (overlap p-value = 3.84E-16).

Based on Chi square test the difference in Fancd2 localization between genotypes is highly significant ( P = 4 × 10 −16 ).

Cochran’s Q statistic was highly significant ( Q = 111.9, df = 31, p = 4.06 × 10 − 16 ).

Additionally, the FarmCPU model identified extremely significant SNP for somatic cell count, fat percentage, and total dry matter percentage traits, located on chromosome 13 (13:2275920, P = 4.14 × 10 −16 ), chromosome 3 (3:14938807, P = 5.75 × 10 −18 ), and chromosome 20 (20:66155928, P = 1.03 × 10 −18 ), respectively. 3.5 Positional candidate genes To further investigate the molecular markers and functional genes related to economic traits in goat milk, we identified genes within a 50 kb range upstream and downstream of the significant SNP as positional candidate genes.

Observed richness did not significantly differ by diet regimen ( F = 0.296; p = 0.746) but sample type was highly significant ( F = 106.45; p = 4.38 × 10 –16 ; Figure 4 ).

The summary data showed that the association with the concurrent presence of the three antibodies was highly significant (Fig. 1C , 3 Ab vs . 0 Ab: OR = 2.00, p = 4.4 ×10 −16 , I 2 = 17%), and significantly stronger than the observed with the patients carrying two antibodies when directly compared (3 Ab vs . 2 Ab: OR = 1.54, 95% CI 1.29–1.84, p = 1.4 ×10 −6 , I 2 = 12%).

Furthermore, the association estimated by the IVW method was markedly significant after correction for one outlier variant detected by MR-PRESSO test (OR = 0.46, 95% CI: 0.38–0.55, p = 4.89 × 10 − 16 ).

We observed a highly significant correlation of R = 0.66 ( P ‐value = 5 × 10 −16 ) for the 115 markers represented by the grey (non‐replicating) and orange (replicating) dots.

This functional pathway analysis is highly significant with p < 5 × 10 −16 . 3.

The association of HERC2 and SLC24A5 with eye color is also apparent in individuals who do not have blue or green eyes: In the subset of 592 Cape Verdeans whose T-index >0.15 ( Figure 1 , Figure 2 ), both loci remain highly significant ( HERC2 rs12913832, P = 5.23×10 −16 ; and SLC24A5 rs2470102, P = 1.12×10 −10 ), indicating that variation at these loci affects different shades of brown eye color.

This association of mimps with SIX gene promoters is highly significant (chi-square test p = 5.25E-16 for association by chance of mimps with the six known SIX genes on the Fol4287 pathogenicity chromosome).

Against a background of 19,297 protein-coding genes, this corresponds to a highly significant enrichment (hypergeometric test p-value = 5.9×10 −16 ).

This revealed marked and highly significant reductions in total dendrite length in both apical (p=6.02×10 −16 ) and basal (p=4.75×10 −14 ) compartments of Cd40 -/- mice compared with Cd40 +/+ littermates ( Figure 1C ).

In addition, there was the fourth cluster: (4) "Response to chemical and xenobiotic stimulus, drug metabolism", including the highly significant pathway "Drug metabolism–cytochrome p-450" ( p < 6.25e−16) containing cytochrome P450 enzymes (CYP2C, CYP3A, CYP26, UGT, GSTs).

A multivariate regression analysis of age-adjusted PAI-1 (dependent variable) reveals highly significant associations with liver density (P=6.3x10 -16 in Model I) and VAT volume (P=1.0x10 -13 , Model II in Supplementary Table 3.3 ) even after adjusting for BMI and other confounders.

We also found highly significant negative correlations of tumor purity with both immune scores (Pearson r = −0.988, P-value = 6.42 × 10 −16 ) and stromal scores (Pearson r = −0.917, P-value = 1.36 × 10 −8 ).

The log-normal regression (script 1, Supplementary material 1 ) revealed: (i) a highly significant influence of the zones ( p = 6.600e−16) and the season ( p = 6.219e−08) ( Fig. 4 ).

Combined analysis of the GERAD1 and EADI1 data yield highly significant support for all three loci ( CLU meta- P =6.7×10 −16 , PICALM meta- P =6.3×10 −9 , CR1 meta- P =3.2×10 −12 ).

2 C), and the difference from SBS homomers is highly significant ( Fig. 2 G, p = 6.9e − 16, ANCOVA for distances 25%–60%).

While the baseline tracking time for short words did not differ significantly between L1 and L2 readers ( p >0.05), the group × length interaction was highly significant ( p < 7 e −16), indicating that L2 readers show a steeper increase in tracking time for long words compared to L1 readers.

In expectation with known gene families involved in insecticide resistance, we observe highly significant enrichment for many GO terms relating to detoxification, such as oxidoreductase activity (fdr-corrected p value = 8e-16), iron ion binding ( p = 4.75e-15), heme-binding ( p = 6.8e-14), monoxygenase activity ( p = 9e-14), glutathione activity ( p = 0.001) and glutathione metabolic process ( p = 0.001), and the ‘P450’ ( p = 1.6e-16), ‘GST_N_3’ ( p = 0.002) and ‘GST_C’ ( p = 0.004) protein domains.

This module also demonstrated a highly significant hypergeometric enrichment ( p = 8e-16; Supplementary Table S3 ) with the mouse “yellow” module, which we previously showed was enriched with microglia genes as well ( p = 2.28e-37).