highly significantp < 6.25e−16
In addition, there was the fourth cluster: (4) "Response to chemical and xenobiotic stimulus, drug metabolism", including the highly significant pathway "Drug metabolism–cytochrome p-450" ( p < 6.25e−16) containing cytochrome P450 enzymes (CYP2C, CYP3A, CYP26, UGT, GSTs).