A predominant involvement of the triple seropositive patients and others with rheumatoid factor in the association of smoking with rheumatoid arthritis.

The summary data showed that the association with the concurrent presence of the three antibodies was highly significant (Fig. 1C , 3 Ab vs . 0 Ab: OR = 2.00, p = 4.4 ×10 −16 , I 2 = 17%), and significantly stronger than the observed with the patients carrying two antibodies when directly compared (3 Ab vs . 2 Ab: OR = 1.54, 95% CI 1.29–1.84, p = 1.4 ×10 −6 , I 2 = 12%).

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