Excerpts

A highly significant positive correlation ( r = 0.74, P value = 8.8*10 −16 at 95%, CI = [0.62,0.82]) of BC with infection counts and with Death considering 10 days lag ( r = 0.84, P value = 2.02*10 −13 at 95%, CI = [0.73,0.91]) for the entire period, supports the above interpretation ( Fig. 2 (a, b)).

With additional adjustment for visceral fat, the association between rs738409 and percent liver fat was highly significant ( P = 8.88 × 10 −16 ; data not shown).

To determine the biological relevance of TDP-43-regulated APA, we studied its effects on microtubule affinity regulating kinase 3 (MARK3), a highly significant ( P = 9.4 × 10 –16 ) hit from APA analysis of ALS/FTD frontal cortex neuron nuclei containing or depleted of TDP-43.

Combining replication evidence from all 6 cohorts revealed an overall highly significant deviation from the expectation under the null (KS test p = 9.7 × 10 −16 , Fig. 4h ).

This showed a highly significant increased risk of MS associated with smoking with no significant statistical heterogeneity (RR 1.48, 95% CI 1.35–1.63, p<10 −15 , heterogeneity: χ 2 = 7.38, p = 0.60; figure 1 ).

The association between C/EBP δ mRNA expression and sensitivity to panobinostat is replicated in LC 2 from CTRPv2, with the pairwise relationship also being highly significant (Spearman ρ = −0.30, p < 1 × 10 −15 ).

Here we identify associations between microbiome diversity and both moderate physical activity (MPA; times per week) and vigorous physical activity (VPA; times per week) that are highly significant (Fig. 3 ; P < 10 −15 and P < 10 −15 , for MPA and VPA, respectively).

Data from a large cohort of individuals with sports concussion were examined and also demonstrated that differences in mean values of reaction time and reaction time variability (with the Brain Gauge) are statistically highly significant between healthy control and post-concussion populations ( p < 10 −15 ; Tommerdahl et al., 2020 ).

Analysing the combined amino acid composition of the complete proteomes, we indeed find a small but statistically highly significant shift in ERK of endothermic compared to ectothermic vertebrates (Figure 3 ; Wilcoxon rank sum test: p < 10 -15 ).

This enrichment of accelerated blocks near duplicated genes is highly significant (FET: P < 1 × 10 −15 , OR = 8.41 [95% CI, 7.18–9.82]; see row one in table 3 ).

The difference in LAMconcentration between the cases and controls was highly significant [ P < 1 × 10 −15 , n = 101, Wilcoxon signed-rank test; difference in location estimate, −247.318; 95% confidence interval (CI), −351.3 to 200.8; Fig. 3 ].

Notably, the PluriUp gene module contains 86% of the PluriNet genes (Figure 6B ), a highly significant overlap by Fisher's exact test (p < 10 -15 , Additional file 3 , Table S6).

This association is highly significant ( p < 10 -15 ).

The baseline method ROTS that ignores longitudinal trends also performed well with an IQR mean pAUC of 0.941, while the difference to the best performing method RolDE was highly significant ( p < 10 −15 ).

Application to the present data indicated that TT has a very highly significant effect on hit rate (p < 10 -15 ), as shown in Table 1 .

Analysis of the number of crystal packets among the studied species revealed highly significant differences in their frequency of occurrence (ANOVA, p < 10 − 15 ).

This difference is highly significant ( p < 10 -15 , χ 2 -test, df = 1).

Similarly, we found slightly reduced but still highly significant correlations using expression differences normalized to the average variation (effect size) (Pearson's correlation R = 0.566, p < 10 -15 and R = 0.584, p < 10 -15 , respectively).

The overlap of DTA and DGE events identified across all three data sets was highly significant (phyper P < 1 × 10 −15 ), confirming the robustness of our findings.

Highly significant linkage disequilibrium was found between the cream locus and SNP8 (LRT = 88.5, P < 10-15 ), SNP1 (LRT = 41.6, P < 10-10 ) and Del (LRT = 32.5, P < 10-8 ).

A massive and highly significant ( p -value <10 −15 ) decrease of TAT expression is observed in tumors as compared to their adjacent tissue in most of the samples (87/112, median decreased of 20 fold, Fig. 6 ).

The Kruskal–Wallis test revealed a highly significant difference among groups ( H = 10,029.68, p < 1 × 10 −15 ).

This module includes 44 DEGs, which is a highly significant enrichment (Fisher’s exact test, Odds ratio = 75.84, P < 10 −15 ).

The correlation coefficient was r = 0.93 and highly significant ( p < 10 −15 ).

This overlap is highly significant (p < 10 −15 , hypergeometric distribution), indicating that CUT&RUN correctly recovers a large portion of previously identified R-loops.