Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Nat Genet · 2011 · PMC3084173 · PMID 21460840

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP =6.7×10 −16actually significant

Combined analysis of the GERAD1 and EADI1 data yield highly significant support for all three loci ( CLU meta- P =6.7×10 −16 , PICALM meta- P =6.3×10 −9 , CR1 meta- P =3.2×10 −12 ).

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nominally significantP <0.05actually significant

rs610932 shows nominally significant association with expression levels of MS4A6A in cerebellum and temporal cortex (0.01< P <0.05; see Supplementary Table 5 ), but not in frontal cortex, pons, or lymphoblastoid cell lines.

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