Barely Significant

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a trend towards significancep = 0.0771.5× alpha
While this elevation only showed a trend towards significance (p = 0.077) this is likely the result of the large variability in KYNA levels in the 5 week post-tamoxifen cohort, but even the lowest KYNA concentration in this group was ~ 6.5-fold higher than the highest concentration in the control cohort.
a positive trendp = 0.0771.5× alphagold
In cerebellum the reduction of soluble mHTT levels was less pronounced and there was more variation in the levels of the aggregated form of the mHTT protein, but nevertheless resulted in a positive trend towards reduction was observed for both mHTT protein forms after (CUG)7 administration (soluble: p = 0.077, aggregated: p = 0.066) ( S2B Fig ).
approached significancep = .0771.5× alpha
The model predicting the sensory aspects of pain approached significance, F (3,48)=2.44, p = .077, R 2 = .131, with a significant association with HPD ( β =1.38, p = .017), a marginal association with BPD ( β =-.82, p = .078), but no association with SPD ( β =.64, p = .183).
Pain perception in personality disorders.
PLoS One · 2025 · PMC12063798