Barely Significant

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near-significantp = 0.0521.0× alphagold
In the intervention group, results showed a near-significant difference between group means for change in total IBS-SSS score ( p = 0.052), and significant differences for ‘Diarrhea’ ( p < 0.001), ‘Constipation’ ( p < 0.001), ‘Bloating and flatulence’ ( p = 0.03) and ‘Intestinal symptom’s influence on daily life’ ( p = 0.038).
marginally significantp = 0.0521.0× alphagold
All ANCOM2-detected differentially abundant bacteria between the two groups were also confirmed to be significant using the MaAsLin2 method ( p < 0.05) with or without adjusting for covariates, except Haemophilus parainfluenza , which was marginally significant ( p = 0.052) in MaAsLin2 after covariate adjustments.
tendency toward significancep = 0.0521.0× alphagold
However, a tendency toward significance ( p = 0.052) was observed at week 12 in the severity of dizziness, with three more participants reporting minimal and one participant rating slight severity of dizziness, with most of the change observed in the PE-1000 group.
a clear trendp = 0.0531.1× alphagold
A clear trend was observed in the cornus ammonis 1 (CA1) and cornus ammonis 3 (CA3) cell layers (Kruskal-Wallis: CA1; p = 0.053, CA3; p = 0.064), where PKU mice on diets without SNC showed a reduction in PSD-95 OD of 44% in the CA1 and 51% in the CA3 compared to WT mice.
borderline significancep = 0.0531.1× alpha
General Patients’ Characteristics and COVID-19 Among the patients, female patients appeared more frequently positive in the anti-SARS-CoV-2 serological test compared to male patients, with borderline significance ( p = 0.053), but no significant differences appeared in terms of the severity of the COVID-19 symptoms.