Barely Significant

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We found a strong spearman correlation of 0.21 ( P = 1.5 × 10 −235 ) between nominally significant estimates of h ^ Y and the MR-IVW absolute deviation from the weighted estimate (Fig. 5c ) (Supplementary Data 13 ), suggesting that MR-link-2 detects region-specific pleiotropy accurately (without the knowledge of estimates from other regions).
A clear trend of the dependence of fasting blood glucose level on the optogenetic manipulation was observed. iLight-mediated insulin production in the liver decreased the blood glucose in both WT and Blvra −/− mice, with lower blood glucose levels in Blvra −/− mice (12.93 mM in WT mice versus 9.26 mM in Blvra −/− mice) (Fig. 6f ).