Excerpts

Intriguingly, the transcript levels of most candidate genes showed a moderate to strong correlation with the H3K27ac ChIP-seq signals of the associated SEs, with marginal significance in HMCLs and primary patient samples (r > 0.4, p < 0.1, Supplementary Fig. 4e ).

For provinces in the Lombardy region where at least ten samples were available, there was a positive trend between the proportion of dogs that tested positive and the recorded burden of human disease (Spearman’s r = 0.771, p = 0.103) (Fig. 2 ) (Source data S2).

However, the T-αFGL2 cells showed a trend toward enrichment in core T RM genes when compared with T-Ctr cells (Supplementary Fig. 8f , NES = 1.23, P = 0.107), suggesting that T-αFGL2 treatment does not directly transform regular T cells into brain tumor–specific T RM cells.

Food elimination was marginally insignificant ( p = 0.10844).

We also observed a strong positive correlation between the rarefied ARG richness and the antibiotic usage rates for the WHO statistics for ARG_cluster95 ( r = 0.86, p = 0.0063) although for the CDDEP it was only marginally significant (see Fig. 2 e-f: r = 0.57, p = 0.11).

Although the study was not powered to compare the two vaccinated groups, the comparison of the viral acquisitions between ALFQA and Alum groups showed a trend towards further delayed viral acquisition ( p = 0.11; Fig. 1d ), but this was not significant.

However, while there was an overall trend for higher diversity in XY compared to XX mice, these effects were not significant ( P = 0.11, 0.11, 0.086).

The prevalence of conjugative pKPN-US-1 showed an increasing trend over time (slope = 0.005, P = 0.11), although this trend was not statistically significant.

The IVSN fIOR model showed lower performance than the IVSN model but this difference was not significant or marginally significant (Experiment 1: p = 0.11; Experiment 2: p = 0.02; Experiment 3: p = 0.07).

This analysis likewise showed a trend in the same direction ( β = −0.02, 95% CI [−0.05, 0.005], SE = 0.014, p = 0.11; Fig. 3B ).

Although high BPTF expression showed a trend toward reduced overall survival in a GEO dataset, the difference did not reach statistical significance, likely due to limited sample size ( p = 0.115; Fig. 7A ).

In the 3 liver lesions that we isolated, VIM transcripts were significantly up-regulated ( P < 0.05 ), ZEB1 and ZEB2 transcript levels showed a trend to increase ( P < 0.12 and P < 0.25, respectively) (Fig. 3i ).

However, phylogeny was not quite significant (MRM, p = 0.12), likely due to the reduced sample size.

For the original 0.5 MU per subject treatment, we find a trend towards significance in the opposite direction to RGN, namely that the quicker half of the subjects contribute less (43%) than the slower half (53%, t (169)=1.54, P =0.12).

We further validated this potential causal relationship using SomaScan pQTLs 47 (Methods), where the weighted median estimator 48 showed significant result (OR = 0.89, 95% CI: 0.81-0.98, p -value = 0.019) while the IVW estimator was close to significance with the same direction of effect (OR = 0.94, 95% CI: 0.87–1.02, p -value = 0.12).

2a ), although this anti-correlation is only marginally significant ( R =−0.39, P ~0.12).

A comparison of Receptor-ITH between Grades 2 and 3 showed a trend toward reduced ITH with cancer progression ( p = 0.12; Fig. 2E , Supplementary Data 3 ).

Although not statistically significant, gSF mice showed a trend toward greater expansion of dominant T cell clones, compared to gSC mice ( p = 0.1219) (Fig. 5e ).

However, expression of hsa-miR-106b-3p was too low to allow replication by qPCR, and the adjusted p -value for hsa-miR-25-3p fell short of significance ( p = 0.125, Supplementary Data 1 ).

Analysis showed a trend to a negative correlation (Pearson r ≈−0.3, P =0.127) between IFNγ gene expression and A. muciniphila levels ( Fig. 5d , top gene).

Analysis of protein synthesis in acinar cells from wild type and Nfic -/- mice using flow cytometry showed a trend, albeit non-significant ( P = 0.13), towards reduced translation in KO pancreata (Supplementary Fig. 8D ).

As such, there was only a weak trend between IL7R – CD8 + T cells and time-to-progression ( p = 0.13, log-rank test; Fig. 7C ).

When the modified percent score (MPS) was assessed as a continuous scale, we found a nonsignificant trend of higher MPS in patients with PFS-6 ( p = 0.13, Supplemental Table 6 ).

5 , Supplementary Table 11 , BMR: p = 0.019, rsq = 0.13; temp: p = 0.005, rsq = 0.22), whereas those with organization were marginally insignificant (BMR: p = 0.13, rsq = 0.08; temp: p = 0.065, rsq = 0.15).

10 ), with a negative trend between EG12 and both PFS ( r s = − 0.714, p = 0.136) and OS ( r s = − 0.371, p = 0.497).