Excerpts

Moreover, we observed a marginally significant ( p = 0.07, Mann–Whitney test) difference in the number of DRMs of NS3-specific DAAs (4–10) and multi-protein DAAs (8–16).

unsolved HRD cases showed borderline non-significant enrichment for rs118031911/T in unsolved cases ( p -value = 0.07, OR = 2.30, CI = 0.94–6.76, by Fisher’s exact test), possibly indicating that either well-defined triallelism does not take place for this variant or that we did not have enough power to detect it.

miR-143/145 +/− marrows also showed a trend toward reduced LT-HSC ( P = 0.07). miR-143/145 −/− and miR-143/145 +/− mice had similar marrow cellularity to WT mice suggesting a deficit in absolute number of HSC (Fig. 1b ).

3c ) with one additional gene, NIPAL3 , marginally significant ( P = 0.07 by case-control analysis) (Fig. 3c ).

6e ), however, in adult mice there was a slight trend for higher apoptosis in newly generated oligodendrocytes in hM3Dq/GFP mice compared to controls ( P = 0.07, n = 4 mice, Welch’s corrected t -test; Supplementary Fig. 6f-h ).

After adjusting for sex, this association remained nominally significant (HR = 4.48 [0.90–22.23], p = 0.07), consistent with our findings showing MS3 as at higher risk of MI (Fig. 4D ).

Below 4100 m, E SMR demonstrated an increasing trend with elevation (approaching statistical significance, P = 0.07), whereas above this threshold, E SMR remained relatively stable with minimal and statistically insignificant variation.

To independently confirm this, we performed a one-way analysis of variance (ANOVA) on the TDA-identified subject subsets, confirming significant drug effects on MN sparing ( P =0.02) and tissue area at the epicentre ( P =0.002), with other outcomes approaching significance, including grooming at 28 days post lesion (DPL) ( P =0.07).

Consistent with our original report, there was a favorable trend to improved OS with melanoma cognate help (HR 0.64, 95% CI: 0.40–1.04, P = 0.07, Addendum Figure 1A; original report: HR 0.65, 95% CI: 0.40–1.05, P = 0.08), with delayed separation of the curves starting at 2.5 years and progressive widening of the curves such that the OS estimate for the 12MP + 6MHP regimen exceeded the upper bound of the 95% CI of the OS estimate for the 12MP+tet regimen at 8 years (Addendum Figure 1B).

The frequency of minor GP lineages in the placebo group was lower in the VRC01 group (14%; 15/105) compared to those in REN (25%; 17/67), with a trend toward significance (Fisher’s exact test two sided: p = 0.07) Recombination was pervasive, as revealed in individuals with multilineage infections.

ETV score was only a marginally significant predictor of prison violations after impression sensitivity and trust behavior were accounted for (direct effect = 0.622 ± 0.340, p = 0.070).

Post hoc tests showed a trend toward a difference between the DMF and LF groups (Bonferroni corrected Mann–Whitney U -test: Z =2.55, P =0.07, two-tailed), and controls ( Z =2.40, P =0.1), and no other notable differences ( Z ≤1.36, P ⩾0.9).

In addition, correlation analysis of the dataset revealed a positive trend between Bmal1 and Dpp4 expression across time points (r2=0.142, P = 0.070).

AlzCV Braak 3-4, p = 0.006) and showed a trend to be greater in AlzTREM2 cases compared to AlzCV Braak stages 5-6 ( p = 0.07; Fig.

This trend reached near significance ( P = 0.07, exact Wilcoxon test) in groups administered with CH505 sequential gp120 Envs when they were formulated in AS01E ( N = 8), with mean autologous tier 1 (CH505.w4.3)-neutralizing antibody ID50-titers of 2264 ± 2932, relative to those administered with CH505 TF Env gp120 alone formulated in AS01E ( N = 8), which by comparison, induced mean autologous tier 1 (CH505.w4.3)-neutralizing antibody ID50-titers of 630 ± 383.

By day 49 post-stroke, a strong trend towards an increase in CD206-expressing cells was observed, which is indicative of macrophage involvement in tissue remodeling and homeostasis (*Fig. 5g, h , p = 0.07, t -test).

The ANOVAs that were significant or trending toward significance ( P ≤0.07) were followed by Tukey HD post hoc tests to examine mean differences between treatments while controlling for familywise error.

2C ), and showed a trend towards greater activity in the no-boating treatment ( t 20.0 = 1.91, p = 0.071; Fig. 2D ).

SC3 inhibitory activity became non-significant with the double mutation although the decrease in Vmax was close to significance ( p = 0.071), suggesting that SC3 may have some activity on the double mutant Drp1.

For LUZP4, differences between seminoma and nonseminoma were more pronounced in ELISA (mean difference = 0.863, t = 3.658, p < 0.001), while phage-based detection approached significance ( t = 1.912, p = 0.071).

Four transporter activity GO terms, including ion channel activity, cation channel activity, substrate-specific channel activity, and cation transmembrane transporter activity, had borderline significant associations with lung cancer (Fisher’s exact test, P = 0.071, 0.073, 0.080, and 0.098, respectively) (Table 4 and Fig. 2 ).

A regression analysis showed a trend for the τ decay to be inversely related with the increase in γ (Fig. 2r ; p = 0.0712, F (1,21) = 3.61).

Consistently, dietary supplementation of ARA to T.mu -free Blt1 −/− mice showed a trend toward increased serum anti-OVA IgA ( p = 0.0714) but failed to increase mucosal anti-OVA IgA levels (Supplementary Fig.

Whereas overexpression of sirt5 in wild-type animals did not lead to a significant change in OCR, Sirt5 significantly increased the OCR in sucla2 mutant zebrafish ( p = 0.0067) and showed a trend towards increased basal respiration ( p = 0.0725) (Fig. 5a–c ).

A previous study in this site observed a small negative and only marginally significant effect ( P = 0.073) of plant diversity on yield, and this influence was driven mostly by herbicide application in barley monoculture treatment and not due to plant richness per se 39 .