Barely Significant

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marginal significancep = 0.0541.1× alphagold
In a fully saturated model simultaneously including sex, mechanical ventilation and comorbidity count (six predictors for 33 events, well beyond the events-per-variable limit), the AISI effect retained a comparable magnitude (aOR 2.57) but reached only marginal significance (95% CI 0.98–6.72, p = 0.054), an attenuation attributable to over-parameterization rather than to loss of signal, and one that underscores why the pre-specified parsimonious model was the appropriate primary specification.
borderline significantp = 0.0551.1× alphagold
Furthermore, epicardial adipose tissue density significantly increased after contrast administration ( p < 0.001), with a median difference of 8.2 HU (IQR 4.3–12.1 HU), whereas either a borderline significant or no significant difference was observed between unenhanced and contrast-enhanced density values of paracardiac and subcutaneous adipose tissue ( p = 0.055 and p = 0.180 respectively), as shown in Figure 5 .