Excerpts

Dendritic spine density on dendrites in the vicinity of FXS hi-Astrocytes showed a trend toward increased density ( Figure 7 B, CTR: 2.54± 0.21, FXS: 3.48 ± 0.42, p = 0.082).

Time to complete healing also showed a trend towards efficacy ( p = 0.0829, Kaplan–Meier) with 0.1% RGN-259.

Additionally, time to complete healing tended to be faster for study eyes treated with RGN-259 than those eyes treated with placebo with near significance ( p = 0.0829, Kaplan–Meier analysis).

Procedural interventions such as lumbar drainage, mechanical ventilation, decompressive craniotomy, and extraventricular drainage did not differ significantly between groups, although lumbar drain use approached significance (47% vs. 62%; p = 0.083).

In the multivariable regression model, S100B serum levels approached significance (OR (95% CI) 1.03 (1.00–1.06), p = 0.083), suggesting a potential association with MCI.

The comparison between Group 2 (HC-MCI-AD) and Group 3 (MCI-MCI-AD) showed a trend towards significance ( p = 0.083) but did not exceed the conventional threshold.

Besides, we found a negative trend for PACAP-38 and erythrocyte sedimentation rate (ESR) ( n = 25, p = 0.0833, r = −0.3531), urinary total protein (UTP) ( n = 23, p = 0.0522, r = −0.4191) and serum kappa/lambda ratio (KLR) above 1.65 ( n = 18, p = 0.1144, r = −0.3849), but there was a positive trend with KLR below 0.26 ( n = 8, p = 0.1323, r = 0.5952).

The LV anterior wall thickness (AWT) exhibited a nonsignificant trend ( p = 0.0836) towards increased thickness in WT 4 week, as compared with EA1-treated, but there was no difference between these groups in the EphA2-R-M mice.

In the bivariate model including both CD86 expression on NCMs and bilirubin, the prognostic effect of CD86 + NCM was attenuated but remained evident as a strong trend (HR 0.9994, 95% CI 0.9987–1.0001, p = 0.084), while bilirubin lost prognostic significance (HR 1.44, 95% CI 0.68–3.06, p = 0.34) ( Figure 3 F; Table S1 ).

Among this group, TCA, TCDCA, and GCA showed a significant increase also when individually considered, while GCDCA was not strictly significant ( p = 0.084) but moved alongside its physiological group.

Indeed, an increase in relative formate levels in tumour tissue compared to surrounding tissue was the most consistent and nearly significant metabolite change overall (Wilcoxon signed-rank test, p = 0.084). 2.5.

As shown in Figure 4 B, although ethanol did not produce a statistically significant difference in Hsp70 levels, there is a marginal trend towards being elevated 24 h after ethanol treatment ( p = 0.084).

Concomitantly, we showed a trend towards an increased expression of CerS4 at the beginning of the study (first week: p = 0.0842; Figure 2 C).

In the open field test (OFT, Figure 1 Biii), no significant between-group differences were observed in total distance travelled, time in the arena centre nor the frequency of rearing, digging or grooming over the course of the study (although Chow-P results were universally higher than Chow-C after 24 weeks supplementation with a trend toward significance for digging: 84.8%, p = 0.0847).

The non-zonal group showed a trend to more bone retention than zonal defects ( p = 0.085; Figure 2 c).

The BDNF rs6265 × childhood maltreatment approached but fell short of significance ( p = 0.085) (see Supplementary Table S6 ).

Furthermore, there was an increasing trend between endometriosis ( n = 77; 6.65 ± 2.76 ng/mL) and the O-patient group ( n = 22; 9.99 ± 6.76 ng/mL) ( p = 0.085) ( Figure 5 ).

Separate ANOVA focused on data related to the Familiar social stimulus only indicated that perinatal treatment, per se (F 2,42 = 1.943, p = 0.155), and drug (F 1,42 = 0.218, p = 0.643) were not significant, while their interactions just missed significance (F 2,42 = 2.605, p = 0.085).

Our experiment with the administration of cromolyn after tumor formation also showed a trend in decreased tumor weight and volume, although with p = 0.0858.

However, multivariate analysis showed that the association between the GNB3 polymorphism and the risk of MI or acute PAOD was not statistically significant but was close to the level of significance (MI, p = 0.086; PAOD, p = 0.05).

Eosinophils showed a trend towards a decrease in the absolute number of cells ( p = 0.086) but not in percentage ( p = 0.251) ( Figure 3 A,B).

Although the differences were not significant for HLA-DRB1*07:01 and DRB1*15:01, they appeared to be marginally significant ( p = 0.087 and p = 0.084, respectively).

Although there was a clear trend of an increased level of AQP4 in APP/PS1/eNOS +/− mice (22% increase; Figure 7 D,G), this difference was not statistically significant ( p = 0.087).

Interestingly, the same SNPs showed a trend of association with improvement at the PANSS negative subscale, also in the genotypic analyses (respectively p = 0.087 and p = 0.09).

R 2 = 0.081), and the overall model is marginally significant ( p = 0.087).