Excerpts

The study did not reach statistical significance in the intention-to-treat population, with a median PFS of 5.7 months for selinexor versus 3.8 months for the control arm (HR 0.70; p = 0.024).

Although lacking tumor specificity, high GLUT1 levels, characterized by both high extension and high staining intensity, showed a trend association with the presence of metastases and associated with distant recurrence ( p = 0.026, Table 4 ), reinforcing observations from other authors linking this protein to metastasis [ 42 , 43 , 44 ].

Nominally significant associations were observed for NKG2C+ B cells ( p = 0.026) in the overall sample.

In the total subset material, there was a highly significant correlation (Rs = 0.67; p = 0.026) between the difference in expression of the MKi-67 gene and the increase in the percentage of Ki-67- MIB1-positive cells during treatment.

However, the interaction between low IDO and low IL4I1 expression achieved a slightly significant decrease in hazard (hazard ratio = 0.3301, p = 0.0263). 3.

Moreover, the HLA-DR score for UM with no-low pigmentation was lower than in moderately pigmented and heavily pigmented UM, even though the latter comparison did not reach statistical significance (no-low vs. moderate pigmentation: p = 0.027, no-low vs. heavy pigmentation: p = 0.053) ( Supplementary Figure S1e ).

HAs was borderline significant ( p = 0.027).

Magnesium (Mg) was the only element for which the differences between groups were close to significance ( p = 0.027), which may suggest potential deviations in its concentration.

However, as shown in Figure 1 , adjacent and triplet pairs exhibited a significant co-expression tendency compared to random pairs ( p <0.01, one-sided KS test), while quadruplet pairs only exhibited a marginal significance ( p =0.0272).

The α-synuclein results were significant as per the Kruskal–Wallis test ( p < 0.01), and, while the post hoc test only approached significance, the t -test resulted in p = 0.0286 when comparing the PADK group to the vehicle-treated transgenic mice.

However, despite a clear trend of the DRG neurons to show a higher response than the TG neurons show, the difference becomes statistically significant only after two minutes of washout ( p = 0.0292 after two minutes and p = 0.0128 after three minutes of washout, unpaired Student’s t -test).

However, there was a weakly significant linear relationship between the logarithm of chromaticity thresholds to blue CAD stimuli and the logarithm of waveguiding cone densities controlling for age ( p = 0.03, F-test).

Outcomes of IVF Cycles Regarding the results of the IVF cycle, patients with DE and MIX presented lower estradiol levels at the end of stimulation, although these levels did not reach statistical significance, and a lower number of mature oocytes compared to patients without pelvic endometriosis ( p = 0.03).

However the one weakly significant compound ( p = 0.03) had a false discovery rate of 0.4, which made a true correlation unlikely (KW q -values, Supplementary Table S1 ).

While the expression of claudin-1 was also notably higher with TNFα and ML-7 compared to cells treated only with TNFα, just a tendency towards significance could be shown (one-way ANOVA: F (2,9) = 5.30, p = 0.03, n = 4; TNFα: 69.34 ± 5.08%; TNFα + ML-7: 94.31 ± 11.17%, p = 0.079).

This observation was highly significant ( p = 0.03, hypergeometric test).

In contrast, elevated MYC mRNA had a marginally significant negative correlation with overall survival (64 versus 107 months, log-rank p = 0.030, Figure 5 B).

Among the 13 analyzed miRNAs, rno-let-7b-5p showed a nominally significant 1.5-fold increase in serum EVs from allergic rats (unadjusted p = 0.03); no multiple-testing correction was applied.

The analysis for CNS promoter activation was nominally significant ( p = 0.0311).

Even for MKi67, it was barely significant ( p = 0.032) whereas the other subtypes were more significant ( p < 0.001).

This calculation demonstrated a moderately significant correlation ( p = 0.033, τb = 0.52), which could be interpreted to indicate that RBC aggregation is a key determinant but not the exclusive causal factor for COVID-19 morbidity in mammals. 9.

KS distances are larger (0.032–0.038), and likelihood ratio tests consistently favored the lognormal distribution, with negative R values and significant or nearly significant p -values (e.g., R = −4.49 at TM ≥ 20%, p = 0.033; R = −2.52 at TM ≥ 100%, p = 0.075).

In the prelimbic cortex, there was a nominally significant difference in Gdap1 DNAm ( F (1,29) = 4.92, p = 0.035, mean ± SD DNAm AUD = 4.07% ± 0.41%, mean ± SD DNAm Ctrl = 3.66% ± 0.59%, Figure 6 E).

The NEBL rs2359536 and PCDH15 rs10763170 variants were not associated with the overall risk for the disease, although a borderline significant association was observed between the PCDH15 rs10763170 minor allele (T allele) and somatotrophinomas (dominant model, OR 1.55, 95% CI 1.02–2.35, p = 0.035).

However, the PCDH15 rs10763170 minor allele (T allele) presented a near-significant association with somatotrophinomas (dominant inheritance model, OR 1.55, 95% CI 1.02–2.35, p = 0.035).