Barely Significant

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showed a trendp=0.071.4× alpha
conducted a multicenter retrospective study of 130 newly diagnosed older AML patients receiving HMA/venetoclax and found that while pre-existing CKD showed a trend toward lower overall response rates (OR: 0.5; p=0.07), it did not significantly affect overall survival; however, acute kidney injury during treatment was an independent prognostic factor for inferior overall survival (HR: 1.86; p=0.01) [ 15 ].
Drug-induced acute diarrhea showed a trend toward significance (OR = 6.35, 95% CI = 0.84-48.0, p = 0.070), as did age (OR = 1.04, 95% CI = 0.91-1.09, p = 0.074) and age at transplantation (OR = 0.93, 95% CI = 0.87-1.01, p = 0.118), although these did not reach statistical significance.