Excerpts

τ i ≤ 0.89 (s) cutoff value showed borderline significance ( p = 0.098).

However, postoperative NPS was considered marginally significant as a prognostic factor for OS ( p = 0.098). 3.7.

Our data suggested a higher number of recurrences in the group with high expression of miR-24-1-5p but of borderline significance ( p = 0.098) ( Figure 2 ).

In the multivariate Cox regression proportional hazard model, a strong trend could be observed for elevated S100 at baseline (HR 1.78, 95% CI 0.90–3.54, p = 0.098) but not for the high-CCL20 group (HR 1.46, 95% CI 0.77–2.75, p = 0.244) regarding OS ( Table 5 ).

A favorable trend was observed in real-world PFS for patients treated with T-DXd as first- or second-line therapy compared with later lines (17 versus 15 months; p = 0.098).

Though there were no significant differences between the outcomes of subgroups with or without EBRT, the mOS values showed a clear trend in favor of EBRT (673 vs. 517 days, p = 0.0983).

The distribution of single-station versus multi-station N2 disease showed a trend towards significance ( p = 0.099), with Group A having a higher proportion of single-station N2 disease (90%) compared to Group C (72%). 3.2.

A marginally significant decrease in plasma interleukin-6 levels was observed in the CgA − group ( p = 0.0995), while there was no change in the CgA + group ( p = 0.6398).

Significant variables, those of borderline significance ( p < 0.1) and clinically relevant variables were included in the multivariate regression model.

The second included 25 studies with 50,404 patients; the RATS group reported longer DFS than the VATS group (HR 0.76, 95% CI 0.59–0.97; p = 0.03) and a nonsignificant trend toward longer OS (HR 0.77, 95% CI 0.57–1.05; p = 0.10) [ 117 ].

The model with the additional covariates showed marginal significance (at p < 0.10) for social participation ( p = 0.079).

In agreement with this finding, the imaging index virtually preserved its capability to predict the response to treatment in patients with the highest increase in PSA after Ra223 administration, as suggested by the almost significant p value ( p = 0.1 in each subgroup, see also Figure 4 ) and the emblematic example reported in Figure 5 . 4.

We also decided to include in the multivariate Cox’s regression analysis those IIs that showed a trend for significance (a p -value < 0.1).

The difference in C-index between the 5 mm tumour rim and the corresponding core volume showed a statistical trend ( p = 0.10).

Variables that achieved statistical significance ( p < 0.05) or those close to significance ( p < 0.1) by univariate analysis were subsequently included in the multivariate analysis.

Multivariate Cox regression models were explored including ICI type and other covariates presenting a significant or a marginally significant effect ( p -value < 0.1) based on univariate Cox regression models.

Variables that achieved statistical significance ( p < 0.05) or those close to significance ( p < 0.1) by univariate analysis were subsequently included in the multivariate analysis.

Variables showing a tendency toward statistical significance ( p < 0.1) in the univariable model were entered into the multivariable model.

If the global test demonstrated a near-significant result ( p -value < 0.1), then post-hoc Tukey’s multiple comparison test was performed.

In the group of oral cavity/oropharynx, Actinobacteria and Actinomyces approached significance in low T-stage patients relative to higher stages ( p = 0.100, p = 0.192, respectively), while Parvimonas remained decreased among low T-stage patients ( p = 0.006) [ 47 ].

Six months after the end of the treatments, the proportions of Dialister in PS patients who received adjuvant chemotherapy tended to remain higher ( p = 0.1), while in PS patients of the neoadjuvant group, there were significant or near-significant increases in some PR-associated microbial signatures, i.e., Eggerthella ( p = 0.1) and Adlercreutzia ( p = 0.04) ( Figure S7 ).

Statistical Analysis Statistical analyses were performed using R statistical software (version 3.6.1, R Foundation, https://www.r-project.org/ , last accessed 25 October 2021), where a p -value (after Bonferroni corrections for pairwise comparisons using the t -test) of < 0.05 was considered significant ( p < 0.001 presented as **, 0.001 ≤ p < 0.05 as *), 0.05 ≤ p < 0.1 as marginally significant (presented as # ) and p ≥ 0.1 as nonsignificant (presented as ns).

In this context, our exploratory analysis suggested that PTV volume (>13 cc) was marginally significant ( p < 0.1) for toxicity, but this requires validation in the full cohort of 55 patients.

Statistical Analysis Statistical analyses were performed using R statistical software (version 3.6.1, R Foundation, https://www.r-project.org/ accessed on 17 May 2022), where a p -value (after Bonferroni corrections for pairwise comparisons using the t -test) of < 0.05 was considered significant ( p < 0.001 presented as **, 0.001 ≤ p < 0.05 as *), 0.05 ≤ p < 0.1 as marginally significant (presented as #) and p ≥ 0.1 as nonsignificant (presented as ns).

In the univariate model, PRMT7 high showed a trend to increased hazard for an event (HR = 1.81, 95% CI, 0.89–3.71, p = 0.1), but it did not reach statistical significance.