Excerpts

As the BCLC staging system is the most widely used algorithm for treatment allocation and determination of prognosis of patients with HCC [ 2 ], we also performed subgroup analyses stratified according to BCLC stage, and found a significant prognostic effect of the combined score on overall survival only in the BCLC A group, although in BCLC B and C patients, a strong trend was observed ( p = 0.053 and 0.052, respectively) ( Figure 5 c).

Gross total resection showed a trend toward improved survival (HR = 0.563, 95% CI: 0.315–1.007, p = 0.053), though it did not reach statistical significance. 5-ALA remained non-significant in the multivariable model (HR = 0.885, 95% CI: 0.554–1.413, p = 0.608), suggesting that while it improves resection extent, it does not independently affect survival when accounting for other clinical variables. 3.6.

When analyzing survival in all patients (stages I–IV), a borderline significance was observed (HR = 0.87, p = 0.053; median survival in the low-expression cohort = 19.4 months, median survival in the high-expression cohort = 21 months) ( Figure 1 B).

Correlation between CHIP/RIPK3 Expression and Clinicopathologic Parameters Highly positive CHIP expression was significantly associated with squamous histology ( p < 0.001), histologic grade 2–3 ( p = 0.001), and stage II–III with borderline significance ( p = 0.053) ( Table 1 ).

A marginally significant association was further observed in the validation stage with 47 cases and 48 controls using pre-diagnostic samples (OR = 1.28; 95%CI: 0.98, 2.97; p = 0.053).

Similarly, no effect on RFS was found across any stage, although the Stage I patients showed a trend toward significance for opioid use as a risk factor ( p = 0.053).

There were no cytokines with baseline levels associated with rPFS in Cohort 2a (Cox regression p ≥ 0.05, Figure S1c, File S1 ), although IL6 almost reached statistical significance with p = 0.053 (HR = 1.16, 95% CI = 0.998–1.34). 3.4.

Expression of MDL1 and MDL1AS in LARC Patients Predict 5-Year Survival Given the differential expression of MDL1AS between rectal cancer cells and the surrounding normal tissue ( Figure 1 A) and that the differences in levels of expression for this lncRNA were almost significant in patients with long survival when compared to those with lower survival ( p = 0.053, Table 1 ), we decided to study more deeply the connections between the expression of MDL1/MDL1AS and LARC patient survival.

The HLA B44 supertype was found to be marginally non-significant (OR = 1.17 (1.00–1.37), p = 0.053).

Multivariate Analysis of Dosimetric and Non-Dosimetric Data for Acute Grade 2–3 Diarrhea The multivariate analysis ( Table 4 ) showed that V100% ( p = 0.005) and MRD ( p = 0.008) were significant factors for Grade 2–3 diarrhea, while CCRT had a statistical trend ( p = 0.053).

A similar correlation was found in the case of nuclear Gal-8, though statistically this association was of borderline significance ( p = 0.053) only ( Figure 2 and Figure 3 D).

ECR rate was significantly higher in patients with clinically smaller tumors (OR = 2.7, p = 0.002), unifocal type (OR = 4.0, p = 0.035), and on the borderline of significance with Ki-67 proliferative index ≥65% (OR = 1.8, p = 0.054).

Analysis of changes in self-esteem during treatment did not reach statistical significance; however, trends approaching significance were observed for age and BMI ( p = 0.054 and p = 0.066, respectively), suggesting a potential influence of these variables on the dynamics of self-esteem changes ( Table 7 ).

A central area of fibrosis/hyalinization was less frequently detected in G3 tumors, although this finding was borderline significant ( p = 0.054).

We did observe that men with more aggressive localized disease (GS ≥ 4 + 3) showed a trend to have a greater mean WC compared to men with less aggressive disease (GS ≤ 3 + 4; p = 0.054), but there was no difference in mean BMI.

We note that the mean difference between these groups on the interference measure (test 3–test 2) of the Stroop test showed a trend towards significance (incomplete follow up M = −0.35 vs. complete follow up M = 0.07, p = 0.054). 3.3.

In the combination, SBI-457 attenuated sorafenib-induced β-catenin upregulation, trending toward significance ( p = 0.054; Figure 2 C).

Although FDG-PET avidity did not reach statistical significance in the multivariate model, it showed a trend toward worse survival ( p = 0.054).

They were also more likely to choose survival length over balance between side-effects and survival as their main priority when choosing between treatment options, but this was borderline significant ( p = 0.054).

On the other hand, ABCB1 (rs3842) genotype showed a trend of association with MR E/NDM ( p = 0.054) and moderate association with MR E/4-HT ( p = 0.039).

Baseline antibiotics showed a trend toward association ( p = 0.054).

The favorable prognostic impact on PFS of SOCS1 mutations described in the prior report [ 36 ] was maintained, although with borderline significance, also in the cohort analyzed by the present study (2-year PFS 93% vs. 70%, p = 0.054), while there was no evident impact on OS (100.0% vs. 86.8% at 2 years, p = 0.167).

Only lymph node status showed a marginal trend with poor prognosis of TNBC ( p = 0.054).

Other factors potentially altering lymphatic drainage include increased uterine volume, which showed a near-significant association with mapping failure ( p = 0.054).

KRAS mutation status in tumor was marginally significant ( p = 0.054).