“did not reach statistical significance”

The odds of prospective trial registration showed a trend towards significance for industry funded trials, with a 2.5 times greater likelihood of trial being registered prospectively before enrolment; however, the trend did not reach statistical significance.

1e ), while the distal segment (−1550 bp to −1350 bp), segment 3, only showed a trend of reduction, but did not reach statistical significance (Fig. 1e ).

The trabecular separation displayed a decreasing trend in the CDH-13-treated group, but the difference did not reach statistical significance ( Figure 5J ).

Although VE against all-cause diarrhea did not reach statistical significance ( P = 0.26), it showed a trend that is consistent with the results observed after H 2 O 2 -Campy C vaccination.

These children showed a trend for improvement, but it did not reach statistical significance. 18 19 The RCT by Tsorlakis et al 20 involved 34 children between 3 and 14 years of age with mild to moderate CP (GMFCS levels I–III).

It should be noted that, in the previous study [ 8 ], 2.5 mg/kg of U50,488H showed a trend of decreasing maximal wheel-spinning rates, but did not reach statistical significance.

In this study, co-implantation of SC1 with U87MG cells ( Supplementary Figure S2 ) or intravenously treated U87MG tumor-bearing mice with suboptimal dose regimen of SC1 ( Figure 6A ) showed a clear trend for efficacy, although the tumor volume reduction did not reach statistical significance.

Interestingly, a negative trend between MCs per area of tissue and the % predicted FVC was also observed, but this did not reach statistical significance ( online supplementary figure S3 ).

The same results seemed to be found in IVF, a decreasing trend was seen in all semen variables in men with grade 3 compared with the no varicocele group, but it did not reach statistical significance.

Besides, there seemed to be a decreasing trend of total cholesterol, while showed an increasing trend of HDL-cholesterol at all time points (although the results did not reach statistical significance).

The geometric mean fluorescence intensity of cytokine-positive cells showed a trend toward decreased production per cell in YFP + Th17 ΔSTAT3 compared with YFP + Th17 ctrl cells, but this did not reach statistical significance.

The levels of 5-HIAA in serum, medulla oblongata, and ileum of rats treated with cisplatin had an increasing trend, but did not reach statistical significance ( Figure 5A – C ).

Although it did not reach statistical significance, an apparent trend toward decreased UPEC burden in bladder of acidotic HeJ mice likely resulted from increased diuresis caused by ammonium chloride supplementation of the rodent diet (dark cycle urine volume [ml/mouse per day]: 2% NH 4 Cl diet = 1.5 ± 0.2,; p < .05 versus normal rodent diet = 0.80, Table 2 ).

Patients with shorter surgery study periods also showed a trend toward less overall pouch-related symptoms, more solid stools, and less abdominal pain, but this did not reach statistical significance (Table 2 ).

While Figure 3B illustrates an overall trend for participants to reduce the time spent fixating the second target during CMP and Threat, the main effect of Condition on the overall percentage of time spent fixating the second target did not reach statistical significance ( χ 2 (2) = 4.97, p = .08).

Apremilast treatment showed a trend toward reduced lipid droplet accumulation in both GAN and CHOW groups, although this did not reach statistical significance, suggesting a potential role of PDE4 inhibition in improving hepatocellular lipid handling.

Although, these data did not reach statistical significance, there appeared to be a clear trend suggesting that the POLD1 R689W variant functionally impaired the stability of DNA fibers, as shown by the decreased elongation rate upon IR, while having no effect on the ongoing replication process despite replicational stress, as demonstrated by virtually unchanged second pulse origins and stalled replication forks specifically in POLD1 R689W/- cells.

The transcript (ENST00000506244) encoding the full-length protein (SNCA-140), showed a trend for reduced relative expression in PD, but this did not reach statistical significance ( p = 0.055, effect size = −0.48, DRIMSeq).

The expression of Bcl-2 gene did not differ between groups and an increasing trend was observed for Bax/Bcl-2 ratio in CAD patients; however, it did not reach statistical significance (Figure 3 (Fig. 3) ).

During the transition to ambient light, the DM no DR group also showed a trend of attenuation in AFI rise that did not reach statistical significance, while the mild NPDR participants demonstrated a qualitative trend of complete reversal of AFI responses across all three layers that was significantly decreased in the DCP at 5 min compared to controls ( Figure 6 ).

Several studies revealed that patients with coexisting TP53 mutations treated with EGFR-TKIs showed a trend toward lower ORR, shorter PFS, and OS compared to patients with wild-type TP53 that did not reach statistical significance ( 28 – 31 , 68 ).

The ALT level was also reduced with PEG-BR was not reduced but showed a trend toward reduction that did not reach statistical significance.

The OCP or OCA results demonstrated that enrichment of TP53 mutations showed a trend for higher frequency in FLT3 amplification mCRC patients compared with in non‐ FLT3 amplification patients, but the difference did not reach statistical significance ( P = .16).

The Rho-kinase inhibitor Y-27632 also showed a trend toward decreasing the cell flattening, although this did not reach statistical significance. 3.3.

Importantly, we found that levels of these cells were similar in NT and TT, although B cells showed a trend towards reduced levels in the TME, but the data did not reach statistical significance.