For all three genes, the association between mRNA expression level and methylation class membership approached significance after adjusting for multiple comparisons ( HDAC1 , P = 0.03; SIRT3 , P = 0.06; and DNMT3A , P = 0.07).
Higher frequency of invisible sclera was observed in the D and M types, as compared to the S type ( P < 0.001, P = 0.002) ( Table 4 ).Choroidal hyperthickening was more frequent in the CSC group as compared to the control group with marginal significance (36.7% vs. 10.0%, P = 0.030) ( Table 3 ).
No significant association was found between PIRADS score and SVI (p = 0.28), although a significant trend for one–unit increase in PIRADS score was observed even for this outcome (p = 0.03).
However, there was a significant trend for sero-prevalence to decrease with decreasing deprivation (likelihood ratio trend statistic = 4.92, 1 df, P = 0.03).
A series of paired-sample t -tests (with alpha adjusted to 0.05/3 = 0.017 for three comparisons) showed a trend for faster response times after instructions in the eyebrows condition (5.14 vs. 3.72 seconds), t (19) = 2.30, p = 0.03, d = 0.49, but not in the eyes condition (3.87 vs. 4.06 seconds), t (19) = 0.38, p = 0.71, d = 0.07, or in the ears condition (3.69 vs. 4.03 seconds), t (19) = 0.64, p = 0.53, d = 0.15.
In a randomized controlled study (N = 7) that compared IAT to IVT with recombinant tPA for treatment of patients with acute ischemic stroke with major vessel inclusion, Sen et al (2009) also found that IAT showed a trend toward a higher recanalization rate (3/3 patients for IAT and 0/4 patients for IVT; P = 0.03) ( Table 2 ) [ 20 ].
Gene-gene interaction analyses The cohort from Rio de Janeiro showed a trend toward statistical evidence of interaction between TGFA rs1523305 and IRF6 rs642961 (p = 0.03, OR = 1.77) and between IRF6 rs2073487 and TGFA rs2902345 (p = 0.04, OR = 1.60).
While the association between the minor alleles of these two nsSNPs and lower BMI did not reach statistical significance among Health ABC white participants ( Table 2 ), the association did reach statistical significance among white females (rs52820871 P -value = 0.03, rs2229616 P -value = 0.01) ( Table 3 ).
As shown, overlap of genes showing both higher H3K9ac and H3K4me3 in the same species was only marginally significant (hypergeometric test, p≈0.03), and clearly, the overwhelming majority of genes (c. 85%) did not concur ( Figure 2F ).
Of the three alleles tested, only 4a7a, a putative regulatory mutant, males showed a barely significant difference (p = .03) from non-mutant control flies ( CyO balancer) of the same cross indicating that the dominant enhancement (silencing) is dependent upon chromosomal location and not on the w + transgene Pci construct itself ( Figure 4 ).
A positive association emerged for simple sugar intake (OR = 1.71; 95%CI 1.13–2.59) in the comparison between highest and lowest quintile of intake with a significant trend over quintiles (p = 0.03).
We identified a nominally significant association (p = 0.03; Odds ratio (OR) = 3.13) between a 6 kbp deletion in an intron of NEDD4L and increased risk of asthma.
Immunoblotting further showed a highly significant 5-fold increase in α-SMA (p<0.03) and a 2-fold increase in collagen I expression (p<0.03) post-MI, consistent with the pro-fibrotic CF phenotype ( Fig 2B and 2C ).
Furthermore, from NGT to 2-h NDM group, a gradual and significant increasing trend was observed in age ( P = 0.001), BMI ( P <0.001), SBP ( P <0.001), total cholesterol ( P = 0.04), triglycerides ( P <0.001), Log-CRP ( P = 0.007), FPG ( P <0.001), HbA1c ( P <0.001), SUA ( P = 0.002) and proportion of hyperuricemia ( P = 0.002) and hypertension ( P <0.001), but a decreasing trend in the proportion of smoking ( P = 0.03).
When testing for modifiers, non-significant interactions were found except for CS where a borderline significant interaction was found with sex (p = 0.03).
The approximately 40-kDa procathepsin B exhibited a marginally significant increase of 93±27% (mean±SEM; P<0.03) in the PADK-treated group as compared to vehicle-injected transgenic mice samples ( Fig. 4A and B ).
The difference between the best p gain and fixed p gain{exc,inh} settings was not significant ( p = 0.324, Wilcoxon signed-rank test), and the small decreased observed in the best p gain{exc,inh} setting relative to the fixed p gain{exc,inh} and best p gain settings reached borderline significance ( p = 0.030 and p = 0.003, respectively, Wilcoxon signed-rank tests).
While all were negative for rare mutations in a gene-set comprising PD disease-causing and risk genes, another candidate gene-set of 1000 genes functionally relevant to PD presented a nominally significant ( P = 0.03) enrichment of rare putatively damaging missense variants in the PD cases.
Interestingly, by 9 months, all three groups retained higher V CO , though the highest exposure group did not reach statistical significance (p = 0.03, p = 0.03, p = 0.08 for 2.1 ppm, 16 ppm, and 32 ppm, respectively).
Amongst the interactions, only the one between gameplay mode and target contrast approached significance [F(3,60) = 3.2, p = 0.03, η p 2 = 0.14)], while all others remained insignificant (p>0.2).
The interaction between head colour morph and sex approached significance ( Table 2 ) with black-headed males showing a lower frequency of head movements than juveniles (bootstrapping: p = 0.030; Fig 4 ).
Lower FEV1, FEV1%Pred, and FEV1/FVC showed a significant trend with shorter aTL (p = 0.030, 0.029, and 0.037, respectively), while FVC and FVC %Pred did not.
Evaluating the risk reduction by applying selenium and coenzyme Q10 to the middle selenium concentration group demonstrated a highly significant risk reduction (HR: 0.38; 95%CI 0.15–0.92; P = 0.03), even in competition with the same covariates as applied above ( Table 3 ).
Genes (A) with highly significant 10 kb windows (combined p-values ≤ 0.03) were analyzed for presence of highly differentiated single nucleotide polymorphisms (SNPs) with derived allele frequency ≥ 0.05 (F ST (CEU-CHB) ≥ 0.016; F ST (YRI-CHB) ≥ 0.032; ΔDAF CEU-CHB ≥ 0.042; ΔDAF YRI-CHB ≥ 0.070).
Mitochondrial haplogroup U showed a nominally significant lower risk for PD (OR = 0.51, p-value = 0.03, 95%CI = 0.28–0.92).