Barely Significant

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Similar to results from the substitution and insertion experiments, ePE3 (H840A) and ePE3 (H840A + N863A) induced the same frequencies of the correct deletion (on average, 49.6 ± 5.0% and 48.4 ± 5.4%, respectively), but the frequency of unwanted indels induced by ePE3 (H840A + N863A) showed a trend to decrease at the five loci (Fig. 5g and S 7C ).
Therefore, the placental hyperplasia frequently observed in SCNT embryos could be partially improved by farrerol, and this improvement manifested a reduction in weight, a compact structure, and an efficient compression of the spongiotrophoblast (ST) layer, in which the effect by rescued expression of canonical and noncanonical imprints might be significant.
Consistent with the trends based on 16 S rRNA gene sequencing, the number of green fluorescent colonies of the SA-G sensor displayed a decreasing trend, whereas the number of red fluorescent colonies of ST-R sensor were similar over time (Fig. 3d–f ).