Excerpts

In the psychological and social domains, a highly significant reduction was noted after treatment in both groups, and in the environmental domain, a highly significant reduction was noted in the II-sham-IMT group and a significant reduction in the study group.

This highly significant result in a large cohort (with n = 157 paired tissue samples) confirms the trend of a smaller subset ( n = 44) in a previous study [ 7 ].

Moreover, statistically significant differences were obtained in the CGI-I at visit 1 and a positive trend was found in favour of paracetamol 1000 mg/ibuprofen 300 mg in the PGIC at visit 1 and for sitting disabilities in the ODI at visit 2.

The near-significant association with lower education level may indicate unmeasured contextual factors but requires confirmation in larger cohorts.

Mitral A wave ( p = 0.058) showed a trend towards significance, suggesting they may have clinical relevance despite not reaching the 0.05 threshold in this sample size.

NI-BUT Schirmer I, and OSDI showed a trend toward faster recovery in the gel group than in the BSS group.

Association with Interatrial Block Univariable logistic regression analysis did not identify significant associations between IAB occurrence and anatomical or hemodynamic parameters, nor with the type of ASD closure device used ( p > 0.05 for all), although a nonsignificant trend was observed for ASD diameter.

GFAP as a Prognostic Biomarker in Ischemic Stroke GFAP levels did not significantly vary among TOAST subtypes, although a nonsignificant trend in subtype 5 showing the highest levels is visible, especially vs. subtypes 3 and 4.

Vitamin B12 and Atherogenic Index of Plasma (AIP) Across the vitamin B12 quartiles, highly significant differences were found in AIP scores among all B12 groups using one-way ANOVA analysis, which is used as an indicator of atherogenic risk to assess the cardiovascular risk profile (ANOVA: F(3, 20,661) = 143.977; p < 0.001; partial η 2 = 0.020).

This difference showed a trend toward significance but did not reach the conventional threshold for statistical significance ( p = 0.058).

In our series, MAV-LA was associated with shorter operative time, representing an observed trend rather than definitive evidence, and facilitation of technically demanding steps, such as the appendicovesical anastomosis and submucosal tunneling [ 4 , 13 , 16 ].

However, in multivariable analysis, treatment by the MIDCAB cohort showed a near-significant trend toward improved long-term survival.

However, a nonsignificant trend toward more grade I embryos and fewer grade III embryos in the control group was observed.

In the rest of the conditions, no significant results were found, but there was a trend towards significance ( Table 6 and Figure 1 ).

In multivariate Cox regression analysis ( Table 3 ), high NK activity (≥10 pg/mL) showed a trend toward improved overall survival, although it did not reach absolute statistical significance (HR 0.52, 95% CI 0.26–1.04, p = 0.063).

The pooled random-effects hazard ratio was 1.52 (95% CI 1.00–2.33, p = 0.05), suggesting a borderline significant association between the presence of brain metastases and worse PFS, as shown in Figure 28 .

Notably, questionnaire responses showed a small trend toward requesting more details on relatively rare reversible causes of OHCA, which may reflect their often versatile and different presentation, making diagnosis even more difficult.

The strong association of male sex with relapse (OR = 3.150, p = 0.08) approached significance and aligns with established literature [ 4 , 10 ].

When stratified by therapy status, the positive association between adiponectin and NT-proBNP was not significant in untreated patients but was highly significant in patients receiving therapy, with a higher correlation coefficient than in the overall cohort ( Supplemental Figure S2A,D ).

Model B (CAR, NLR): On day 3, CAR demonstrated a negative trend but did not reach statistical significance (OR = 0.07; p = 0.158).

Silicone oil evacuation showed a trend toward poorer visual outcomes, although this did not reach statistical significance.

analyzed 509 patients with congenital lower eyelid epiblepharon and found that a higher BMI showed a trend toward increased risk of severe corneal involvement [ 14 ], suggesting that elevated BMI may not only be associated with the presence of epiblepharon but also with its clinical severity, although the association did not reach statistical significance in their logistic regression model.

Moreover, following adjustment for laboratory variables, IS patients in the higher TyG-SI quartiles exhibited progressively increased 360-day mortality incidence, compared with Q1, the HRs (95% CIs) were 0.85 (0.56–1.29) for Q2, 1.25 (0.85–1.84) for Q3, and 1.98 (1.37–2.88) for Q4, with a significant trend across quartiles ( p for trend < 0.001) ( Table 2 ).

However, this difference became borderline non-significant when men were stratified according to the presence or absence of benign prostatic hyperplasia (BPH).

In univariate analyses, age differences reached only borderline significance, with poorer outcomes observed mainly in individuals over 80 years.