Barely Significant

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Regarding the time to progression of the disease, the estimates were also very stable, showing in fully adjusted models the tendency to a higher risk of outcome for patients with a PLT count greater than 400 × 103/μL, however, with only marginally significant results (HR = 1.64, 95% CI: 0.99–2.73 or HR = 1.64, 95% CI: 0.98–2.76).
Compared to mi-TA, among eligible studies, mi-PA showed a significant trend over reduced mean operative time, despite being within a large retrospective cohort; Walz et al. reported no significant differences in terms of this variable when considering all adrenal benign masses amenable of surgical treatment [ 14 ].
It should be noted that the use of drugs with a demonstrated nephroprotective effect—such as sodium–glucose co-transporter inhibitors (SGLT2i) or glucagon-like peptide-1 receptor agonists (GLP1-RA)—was practically anecdotal at the baseline visit (years 2012–2015); however, we observed a clear trend towards an increase in the prescription of these drugs at the final visit (V2).
Anxiety and depression scorings were decreased at the six-month follow-up; however, statistical significance level was not reached, yet the mean anxiety scoring changed (Cohen’s d = 0.43) from 7.7 (indicating mild symptoms) to 5.3 (no symptoms) ( p = 0.06) ( Table 2 ) and can be considered as borderline significant.