Excerpts

When the patients’ genotypes are considered, both polymorphisms in the homozygous state displayed a trend towards significance but did not reach statistical significance ( p = 0.05, Table 3 ).

demonstrated an increasing trend ( p < 0.05, Figure 3 B,D).

Apart from the loci mentioned above, numerous other loci were identified that may be significant ( p < 0.05, but higher than the significance threshold currently used for GWAS, which is 5 × 10 −8 ).

A total of 25 miRNAs, comprising 10 conserved miRNAs and 15 novel miRNAs, showed highly significant differences in expression during petal growth (using the criteria |log2(FC)| ≥ 1 and p -value ≤ 0.05) ( Supplementary Table S3 ).

Positive highly significant ( p < 0.05) correlations between the AsA content and gene expression were observed in two PMI genes, i.e., Al20224 [correlation coefficient (r) = 0.861] and Al21940 (r) = 0.523, two PMM genes, [Al18038 (r) = 0.601 and Al25631 (r) = 0.496], one GMP gene, [Al23435 (r) = 0.559], two GME genes, [Al2325

Nuclear factor-kappa B showed a decreasing trend in both BJ-5ta and CCD-1064Sk prematurely aged fibroblasts ( p > 0.05, Figure S25 and Figure S26 , respectively).

Tukey’s test, Dunnett’s test, Bonferroni’s Correction and Student’s t -test were used to calculate statistical significance, and the significance level and extremely significant level were set at p < 0.05 and p < 0.01, respectively.

Consistently, from histological analyses of haematoxylin and eosin (H&E)-stained tibia sections, this study also observed an obvious trend of depletion of bone marrow cells following 4 cycles of AC treatment within the lower secondary spongiosa when compared to normal control rats ( p > 0.05) ( Figure 2 B–E).

Although the results failed to achieve statistical significance, rats treated with CDNF or RADA16-I alone showed a trend toward reduced infarct volume (post hoc p > 0.05).

Although odds ratios associated with the CC genotype were between 1.77 and 2.26 indicating an approximately doubled risk of breast cancer, these observations did not quite attain significance at the p < 0.05 level, which may be due to the small number of CC patients ( Table 2 ).

At 24 h post-irradiation, the USH1 fibroblasts showed systematically more γH2AX foci 24 h post-irradiation (GM03889: 1.2 ± 0.2, GM03854: 1.5 ± 0.4, and GM03891: 0.9 ± 0.1 γH2AX foci per cell) than the radioresistant controls (0 ± 0.5 γH2AX foci per cell); however, these differences were at the limit of significance ( p = 0.05) ( Figure 3 A,B).

Data analysis for ACR70 showed a favorable trend toward anti-IL-17 (OR 2.62, 95% CI 1–6.89, p = 0.05, I2 15%).

The AAV9-hTauP301L-APP/PS1 group showed a poorer performance, with a time in right quadrant close to 25% (random), a Tukey’s post-hoc test revealed almost significant tendency ( p = 0.05) between this group and PBS- APP/PS1 mice in the probe session ( Figure 2 D).

Regarding leptin ( Figure 2 C), the group treated with EPG, as observed for IL-6, was the only one that showed a markedly significant decrease in plasma concentrations ( p ≤ 0.05) compared to the other three groups evaluated, with this average reduction equivalent to 67%. 2.3.3.

Based on PAS staining and calculated sclerosis scores, the development of glomerular sclerosis appeared to be milder in the febuxostat-treated gddY than in the untreated gddY mice, but this difference did not reach statistical significance ( p = 0.05) ( Figure 2 B).

MUC16 expression in pre and post-treatment groups using both drugs (methotrexate and cisplatin) was up-regulated and displayed an increasing trend in the placebo (4.31–5.11%), AF(D)NMs (6.13–6.36%) and IV-drug groups (7.67–8.14%) ( p < 0.05), whilst in the NMs (D) group, MUC16 expression was down-regulated (2.67–3.3%) ( Figure 11 ).

This comparison yielded a near-significant strain effect (F (1,44) = 4.01, p = 0.05) with B6J mice directing a greater proportion of their total response towards the active hole ( Figure 2 D), but no sex difference was detected for this variable (sex effect and interactions, p ’s > 0.14).

The combined treatment group showed a trend toward greater tumor growth inhibition compared with belotecan or AZD6738 alone ( p > 0.05) ( Figure 5 b).

After adjustment for multiple confounders, the strength of association for tumor location increased and was of borderline significance (rectum vs. right colon HR = 2.10, 95% CI 1.00–4.44, p = 0.05; Table 2 ).

2.2.9) [ 51 ] software (download date: 25 February 2017) Xiaole Shirley Liu, Cambridge, MA, USA) was used to search for highly significant enriched DNA methylation regions with -m 10 100000 , regions with corrected p -value < 0.05 were referred to as DNA methylation peaks.

Similarly, CS activity was significantly higher in the TS groups compared to the CON group, and significantly higher in the TS2 group compared to the TS4 group, showing an initial increasing trend followed by a decreasing trend with increasing TS duration ( p < 0.05, Figure 4 b).

Data with p < 0.01 were considered as highly significant, with p < 0.05 considered as statistically significant and with p ≤ 0.1 as marginally significant.

Although no individual lipid species remained significant after Benjamini–Hochberg false discovery rate correction, the lipid alterations showed systematic class-level trend which was significant for several lipid classes under Fisher’s combined probability test (as seen in Figure 1 ), and therefore, species-level results are still reported as nominally significant (unadjusted p < 0.05).

Effect of pH on Partitioning of Serine Protease The main and quadratic effects of pH and interaction effect of pH and tie line length showed a highly significant ( p < 0.05) effect on purification factor of serine protease ( Table 1 ).

As shown in Table 5 , a highly significant ( p < 0.05) correlation coefficient (0.85) was found between DPPH scavenging activity and TPC of the extracts, and the correlation coefficient between DPPH scavenging activity and TFC of the extracts was 0.674 ( p < 0.01).