Excerpts

The D1-TX and pre-TX mean IFV values exhibited a borderline significant difference ( p = 0.08).

Weakly and borderline significant associations were also observed both for total vegetables (β = 1.02, 95%CI: [1.00, 1.05]; p = 0.08) and saturated fats (β = 0.97, 95%CI: [0.95, 1,00]; p = 0.06) ( Table 4 ).

Additionally, LUAD TP53/RB showed a trend toward worse progression-free survival (PFS) (hazard ratio [HR] = 2.65; p = 0.08) and overall survival (OS) ( p = 0.058).

When M3R expression was correlated with clinicopathological features in univariate analyses, infiltrative tumor border configuration and a non-mucinous histological subtype showed a trend towards correlation with M3R expression that was not statistically significant ( p = 0.080, and p = 0.070, respectively, Table 2 ).

They reported a statistical trend ( p = 0.08) towards longer operative times in SGAP cases.

In our meta-analysis, MPR was found to be significantly higher in females than in males, with an odds ratio (OR) of 1.82 (95% CI 1.13–2.93; p = 0.01), while pCR showed a trend to be more favorable in females than in males, but the OR of 1.62 was not statistically significant (95% CI 0.97–2.75; p = 0.08).

Multivariate analysis revealed a statistically significant impact of extrathyroidal extension on RAI-R TC at initial diagnosis ( p = 0.016; hazard ratio (95% confidence interval): 5.2 (1.3–19.8)), while primary tumor size >40 mm was barely not statistically significant ( p = 0.08).

When stratified by cancer type, early-onset Hispanic/Latino patients with colon adenocarcinoma showed a trend toward marginal significance in WNT pathway alterations compared to early-onset NHW patients (93.3% vs. 69%, p = 0.08), suggesting potential ethnic-specific variations in this pathway for colon cancer ( Table S4 ).

While the global comparison showed a trend toward inferior survival that did not reach statistical significance (log-rank p = 0.080), subgroup-specific analyses revealed significantly worse overall survival for STAS-positive patients after radical anatomical resection ( p = 0.034).

Multivariate survival analysis, limited by small numbers, demonstrated a trend towards significance for cytotoxic chemotherapy as an independent predictor of mortality with a HR 1.93 (95% CI: 0.93–4.00, p = 0.08), while the other individual treatment modalities were not associated with significant differences in COVID-19 mortality ( Table 2 ).

Of the seven selected genes, LAMC2, FPPS, TNC, RAN and STC2 had significantly higher mRNA levels in PDAC samples compared to the normal adjacent pancreatic tissues, and PTX3 showed a trend approaching significance ( p = 0.08), while RNA levels of UCHL-1 were not significantly increased in tumor tissues.

However, when we evaluated MMP-9 and MMP-2 activity in EDL homogenate (EDL muscles have a similar fiber type composition to TA muscles) via gelatin zymography, we found a strong trend for IRI+BGP treatment to increase MMP-9 activity relative to VEH ( p = 0.08; Figure 4 J,N) whilst also significantly reducing MMP-2 activity compared to VEH and IRI treatments ( p < 0.05; Figure 4 K,N).

With respect to ethnicity, Black ethnicity was the only group to produce interpretable results, which were of borderline significance; compared to White patients, Black patients were 864% (OR 9.64, 95% CI 0.74–126, p = 0.08) more likely to present with late-stage than early-stage anal cancer (see Supplementary Materials Table S6 ).

Mean f values showed a trend towards the difference between the groups ( p = 0.08).

Borderline significant differences were noted in the WNT pathway when comparing GC in H/L patients to NHW GC patients, with WNT alterations more frequent in H/L GC (8.4% vs. 4%, p = 0.08) and APC mutations being significantly higher (3.6% vs. 0.8%, p = 0.05).

When the cfDNA characteristics were correlated with the circulating Chromogranin A levels at the time of analysis, a weak but significant correlation was found for cfDNA concentration (r = 0.356; p = 0.011) and Alu hypomethylation (r = 0.310; p = 0.029), and a nonsignificant trend for LINE-1 integrity (r= −0.250; p = 0.08), as analyzed by Spearman correlation analysis.

The addition of ED to CDR RT showed a trend towards improved efficacy ( p = 0.0807) compared to CDR RT alone, but such an effect of ED was not observed in the context of UHDR RT ( Figure 5 C).

Univariate and multivariate analyses showed a trend toward better prognoses for patients with low PIK3R1 expression compared to those with high expression in terms of recurrence (HR = 0.68, p = 0.081, log-rank, p = 0.079, and HR = 0.064, p = 0.054, respectively; Figure 1 D).

Although the log-rank test showed a marginal significance for gene expression ( p = 0.081), we further validated this finding using primary Ewing sarcoma patient samples.

The univariate analysis showed that children with a ≥20% FT4 decline were of similar age (7.7 ± 5.1 years versus 10.0 ± 5.7; p = 0.200), more often received antimetabolites (84% versus 67%; p = 0.049)) and showed a trend towards more frequent treatment with vinca-alkaloids (92% versus 80%; p = 0.081) compared with those with no decline or a decline of <20%.

In the univariate analysis, vascular invasion (V1) showed a trend toward association with recurrence (OR 2.10, 95% CI 0.91–4.83, p = 0.082), while upper and lower lobe location appeared to confer increased odds, though not significantly.

5.0, p = 0.5772), although a trend towards significance was observed for TILs (20.0 vs. 10.0, p = 0.0828).

In contrast, for OS, no HALP-based cut-off demonstrated a statistically robust association, with only a borderline non-significant result observed for HALP at diagnosis ( p = 0.083), while the remaining HALP-based cut-offs were not significant ( Table 3 ).

According to the size of the tumors, pT1 tumors show significantly lower peritumoral and intratumoral TIL levels than pT2 tumors (Wilcoxon-test p = 0.008 and p = 0.002, with global Kruskal–Wallis p -values of 0.043 and 0.018, respectively), whereas only borderline significant differences in the number of stromal TILs in different pT groups was observed (global Kruskal–Wallis p = 0.083, with a Wilcoxon-test p -value of 0.042 between pT1 and pT2 tumors) ( Figure S1B ).

In our cohort, female sex showed a trend toward association with worse OS (HR 1.49; 95% CI, 0.95–2.35; p = 0.083), although this did not reach statistical significance.