Excerpts

Since the purity corrected p -values were still highly significant for CD74, it is indicated that CD74 is marker of immune infiltration in breast cancer, but from these results, it is hard to pinpoint a certain immune cell type it is associated with.

In addition, there is an obvious trend towards higher missing-data rates in the longer-term follow-up.

However, Equation (3) was selected for further evaluation, since Figure 3 B shows a weak trend that using Equation (4), temperatures along the thermometry probe decrease slightly, and since the risk of not finding a solution was slightly lower in case of Equation (3).

This indicates a mild trend that planning-based steering yields a slightly larger reduction in hot spot temperature.

On the other hand, there was a strong trend with RadScopal treatment with or without immunotherapy to increase CD4 + T-cells ( Figure 4 A) that were not Foxp3 + Tregs for most ( Figure 4 B).

There was a clear trend between radiographically presumed and histopathologically verified tumor response, which did not reach statistical significance due to the small number of enrolled patients.

In addition, in several of our analyses we found only weakly significant p -values close to 0.05 before multiple-testing adjustment.

Aiming at reaffirming our findings, we evaluated its clinical significance in the institutionally-independent OVCAD multicenter validation cohort, which highlighted a strong trend between i-tRF-GlyGCC increased levels and the poor survival expectancy of the patients.

The authors also showed a trend in a higher intra-tumoral expression of MHC genes and increased inflamed tumor microenvironment under treatment.

Over time, the number of published cases per year has shown an increasing trend ( Figure 1 ).

Encouragingly, the studies presented here showed a clear trend toward more invasive coronary therapy even in cancer patients [ 3 , 11 , 25 , 26 , 27 , 28 ].

As a result, the returned prognostic co-mutations were ascertained with three different levels of significance: (1) empirical significance due to imbalanced events; (2) significance with adjusted p -value < 0.05; (3) marginal significance with adjusted p -value falling in [0.05, 0.1].

The negative correlation between mutational burden and age is marginally significant for Caucasian ( Figure 3 I), significant for Black ( Figure 3 J) and not significant for Asian, which may be due to limited sample size. 2.4.

To further study the effects of these factors in an extended panel of cell lines, we selected the aforementioned seven ETS proteins, along with EHF and ETS2, which showed marginally significant reductions in TERT expression, and GABPA, which had been reported in other cancer lineages.

Interestingly, higher doses showed a trend towards better outcomes in this study [ 21 ].

Concerning the covariates VETC pattern, ECOG group, and NASH, we found highly significant relationships between residuals and time, as evidence for the violation of the proportional hazards assumption.

T-test analysis of mean cell numbers at baseline compared to specimens under IL-2 therapy showed a highly significant increase in CD4 + and CD8 + T cells in the group of responders ( Figure 4 b).

The knowledge of the metabolic features governing cancer cell dormancy entry/escape may be significant in developing effective targeted therapies.

Interestingly, SAMHD1 KO cells showed a trend to increased expression of both DNA damage and apoptotic markers compared to wild type cells when treated with platinum derivatives ( Figure 4 C,D and Supplementary Figures S6 and S8 ).

The difference in BMD values and >15% change measurements between males and females younger than 45 years was borderline significant ( Table 4 and Table S1 ).

The results for which p had values were >0.05, and <0.06 was considered a trend towards significance. 3.

Several studies have shown an increasing trend in continuing aggressive care for patients near the end of life, which is costly and may be of low value [ 7 , 8 ].

In many ways, this observation is unsurprising, given that there are quite significant differences between the underlying model structures, their assumptions, and their input parameters.

Highly significant resistance to chemotherapies used in clinics including etoposide, cisplatin and doxorubicin have been reported in cellular models of osteosarcoma under hypoxic conditions [ 49 , 52 ].

Similarly, in long-bone osteosarcomas, S1P 1 expression was associated with an increased risk of death HR = 1.29 (95% CI: 1.00–1.66) at the limit of significance (based on % of stained cells) with regard to overall survival.