Excerpts

In addition, in several of our analyses we found only weakly significant p -values close to 0.05 before multiple-testing adjustment.

Aiming at reaffirming our findings, we evaluated its clinical significance in the institutionally-independent OVCAD multicenter validation cohort, which highlighted a strong trend between i-tRF-GlyGCC increased levels and the poor survival expectancy of the patients.

The authors also showed a trend in a higher intra-tumoral expression of MHC genes and increased inflamed tumor microenvironment under treatment.

When patients were categorized according to ongoing treatment with calcineurin inhibitor (CNI) at the time of vaccination, the difference in antibody concentration was also highly significant. 3.5.

The results showed a trend towards an increase in BRCA1 expression moving from patients with a “high/high” pattern (H-score = 10) to those with a “low/low” pattern (H-score = 70).

Yes, HR = 2.55, 95% CI: 0.96–6.75, p = 0.06 (marginally significant)), and LN/distant recurrence (Yes vs.

However, study data showed a trend towards chemotherapy alone in progression free survival (11 vs. 5.8 months) and overall survival (20 vs. 13.5 months) [ 105 ].

SLIT2 mRNA levels in this study showed a negative trend with methylation levels of cg13281139, but were not statistically significant ( Figure S5 ).

Supporting our in vitro data, we found higher expression of HELLS in murine HCCs arising in a Trp53−/− background compared to Trp53+/+ HCCs as well as a strong and highly significant correlation between HELLS and FOXM1 expression in different HCC patient cohorts.

Again, finally, to benchmark these observations against human GC, we correlated the expression levels of the mature miR-21-5p transcript against the recently reported functional pan-cancer “matrix remodeling” gene expression signature [ 58 ] across the stomach cancer TCGA dataset, and found a highly significant positive correlation between them ( Figure 7 C).

However, considering all the HRD panels, there is an evident trend of higher PFS in crescent order: HRD-negative, HRD-positive, and BRCA1/2 -mutant subgroups [ 52 ]. 4.

There is an increasing trend of H. pylori -negative gastric MALT lymphoma cases, accounting for 6–40% of recent cases [ 7 , 8 , 9 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].

found only a weakly significant increase in the risk of VSCC for women reporting a history of abortion [ 79 ].

The estimates showed a trend towards an increased rate throughout the entire follow-up period ( Table 4 ).

T-test analysis of mean cell numbers at baseline compared to specimens under IL-2 therapy showed a highly significant increase in CD4 + and CD8 + T cells in the group of responders ( Figure 4 b).

The knowledge of the metabolic features governing cancer cell dormancy entry/escape may be significant in developing effective targeted therapies.

Interestingly, SAMHD1 KO cells showed a trend to increased expression of both DNA damage and apoptotic markers compared to wild type cells when treated with platinum derivatives ( Figure 4 C,D and Supplementary Figures S6 and S8 ).

The difference in BMD values and >15% change measurements between males and females younger than 45 years was borderline significant ( Table 4 and Table S1 ).

The results for which p had values were >0.05, and <0.06 was considered a trend towards significance. 3.

Several studies have shown an increasing trend in continuing aggressive care for patients near the end of life, which is costly and may be of low value [ 7 , 8 ].

In many ways, this observation is unsurprising, given that there are quite significant differences between the underlying model structures, their assumptions, and their input parameters.

Highly significant resistance to chemotherapies used in clinics including etoposide, cisplatin and doxorubicin have been reported in cellular models of osteosarcoma under hypoxic conditions [ 49 , 52 ].

Similarly, in long-bone osteosarcomas, S1P 1 expression was associated with an increased risk of death HR = 1.29 (95% CI: 1.00–1.66) at the limit of significance (based on % of stained cells) with regard to overall survival.

With regard to long bones, the expression of GLUT-1 (% of stained cells and IRS score) was, associated with an increased risk of death HR = 1.16 (95% CI: 0.98–1.38) and HR = 1.14 (95% CI: 1.00–1.29) with borderline significance (0.08 and 0.06, respectively).

Abstract Simple Summary In recent years, there has been a clear trend toward personalized therapy procedures in patients with thyroid cancer with the aim to avoid unnecessary overtreatment of patients and to ensure an improved quality of life.