Excerpts

Nonetheless, from 2010 onwards, it is clear from the sequential pooled cumulative meta-analyses results from studies that there is consistently and stably showed an apparent trend toward a poorer response rate to platinum-based chemotherapy treatment with advanced lung cancer patients, which range from 0.73 to 0.68 ( Fig. 5 ).

Adult mortality has been steadily increasing over the recent years in the Pyrenean population, and demographic forecasts, including the present study, predict a negative trend and its near-extinction over the next 50 years if non-natural mortality (i.e. illegal poisoning which greatly affects the adult segment of the population) continues unabated 39 .

Population structure and assignment Global measures of genetic differentiation G, as computed with Genepop, were highly significant for both the NL and LUPS datasets.

For all association tests, a raw P value of less than 0.05 was considered as nominally significant, which was subjected to Bonferroni correction to account for multiple comparison problems.

For tuber-feeding birds, there was no effect of spatial heterogeneity on swan goose density, but a marginally significant negative effect was found on densities of tundra swan ( Table 1 ).

The abundance of bean goose and lesser white-fronted goose first showed an increasing trend at the beginning of the decade and then remained stable ( Fig. 1a,c ).

Several known aging-associated QTLs individually showed no relationship with mitotypes but collectively a weak trend consistent with a role in mit-n compatibility.

Statistical Analysis Toasting Effects According to their relative contents (area under the curve after one hour of toasting) the ANOVA for all 24 samples ( Table 1 ) showed that the temperature effect was highly significant for all compounds.

There was a nonsignificant trend of less lean mass loss in the former compared to the latter rats (16 vs . 33 g, respectively).

Chinese agriculture produces approximately 620 Tg of crop straw every year, with an increasing trend of an annual rate of 1.4% 17 , and approximately 25% of the straw is currently returned to the field 18 .

An interesting trend to note is that vertical widths along the y direction do not significantly change.

There was a slightly decreasing trend in soil available N in treatment T1 (NPK fertilizer alone) and a slightly increasing trend in SOC content ( Fig. 4 ) clearly indicating that the supply of N in this treatment was not excessive.

They infect both avian and mammalian species and may be significant donors of genetic material to emerging human pathogens.

Number of quadrants with infiltrates was also excluded because this variable has too many missing values and it was only marginally significant.

Surprisingly, heat-stressed intertidal Acropora showed a trend of up to 26% lower tissue biomass than the controls whereas heat-stressed subtidal Acropora were able to maintain their tissue biomass ( Fig. 5D ).

The Amur tiger is a priority target for conservation; its population has shown an increasing trend and distribution range has increased rapidly during recent years.

Nonetheless, a clear trend is seen: all samples prepared using acetic acid have a higher crystallinity than the sample prepared with chloroform.

The first group, which included the maternally imprinted MEST (also known as the paternally expressed gene 1 ( PEG1 )) and PLAGL1 , represents genes that had an overall trend of decreasing abundance during pre-implantation development in the bovine.

An increasing trend was found for both up- and down-regulated phosphopeptides, of which there were 42 and 58 after 1 h, 60 and 90 after 4 h, and 67 and 93 after 9 h, respectively ( Fig. 3A ).

In this study, the phosphorylation level of bZIP transcription factor showed a trend similar to that of the 40S ribosomal protein, increasing from 1 to 4 h and declining from 4 to 9 h after SA treatment.

With regard to the ANOVAs comparing secondary outcomes such as change in TQ, THI, TBF12, MDI, and WHOQoL-questionnaires, the main effect of time turned out significant for the change in the TQ score (baseline score: 33.08 ± 18.26; score at week 12: 29.89 ± 19.11) and marginally significant for the THI with effect sizes being moderate to high (for details see left part of Table 3 ).

Given the increased concentration of sphingolipids observed in COMT −/− mice compared with controls, it appears there may be significant alterations in lipid metabolism pathways, which could result in an increased production of ceramides.

In contrast, near-significant increases in risk for gallbladder cancer were observed for gallstone presence with the FEN1 -69G > A GA (OR = 2.3, 95% CI = 1.5–3.5) and the FEN14150G > T GT (OR = 3.7, 95% CI = 1.4–9.8), whereas significant increases in association for gallbladder cancer were observed for gallstone presence with the FEN1 -69G > A GG (OR = 6.8, 95% CI = 2.1–28.31) and the FEN14150G > T GG(OR = 7.2, 95% CI = 2.2–20.2).

Although VS9, VS10 and VS11 secretions showed a trend toward reduced neurites with application, the trends did not meet significance ( Fig. 2D ).

Notably, in several Western population-based studies, mutant BRAF was either strongly associated with clinicopathological characteristics such as older age and female gender or at least showed a trend toward such associations, while this was not the case in the present study 41 42 43 .