Barely Significant

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Our longitudinal studies also showed a trend toward decreases in the percentage of trisomic cells at timepoint 2 (compared to timepoint 1) for the majority of our participants, which is an outcome one would predict if cells with chromosomal instability are being eliminated by immune surveillance, or cell-cycle arrested [ 36 ].
At the time of these initial approvals, results of only two randomized placebo-controlled trials were available: a prematurely terminated and underpowered study by Wang et al., which found no statistically significant effect of remdesivir on time to clinical improvement or mortality rate [ 5 ]; and NIAID’s ACTT-1 trial, which found a statistically significant shorter time to clinical improvement in the remdesivir group, while the effect for mortality fell just short of statistical significance [ 6 ].