Barely Significant

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HEK293a-Shh cells treated with Hhat-#2 siRNA co-cultured with C3H10T1/2 cells (ratio 1∶2) for 2 days during day 2–4 of KD, resulted in a C3H10T1/2 response decrease of 32±10% compared to non-targeting siRNA, but this did not quite reach statistical significance.
The fact that borderline significance in gene overlap was also observed for categories of disorders sharing clinical risk with MDD (i.e. cardiovascular diseases, inflammation and metabolic syndrome) suggest that the same gene sets may also contribute to dysfunctions in peripheral organs through pleiotropic functions of common genes, hence providing putative biological links for the clinical and symptom co-morbidity.