Barely Significant

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For ward patients (n = 571) who were not admitted to critical care during the 48hrs pre or post onset of infection NEWS predicted 30-day mortality (AUROC 0.80, 95%CI 0.73–0.86) better across all values than any other tool (SOFA, 0.73, 95%CI 0.66–0.80; SIRS, 0.70, 95% CI 0.64–0.77; qSOFA, 0.72, 95%CI 0.65–0.80), although the difference for SOFA was not quite statistically significant (DeLong’s p = 0.07), in predicting 30-day mortality but performed significantly better than SIRS (p = 0.003) or qSOFA (p = 0.007).
borderline significancep<0.071.4× alpha
An analysis of the combined survival curves of these three experiments provided statistical power for a more robust analysis resulting in statistically significant (p = 0.05) log-rank tests between survival curves of non-vaccinated, BCG, and BCG-H56/IC31 ® by one-sided and borderline significance (p<0.07) for two-sided analyses (see S4 Fig ).