Barely Significant

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Proteinase K digestion and western blot analysis of brains from prion-infected mice showed PrP Res deposition at terminal disease, with brains from 5 of 6 responder animals appearing to harbor relatively less PrP Res than most non-responders or infected untreated controls, although densitometry revealed these differences to be not quite statistically significant (p = 0.057 and 0.072, respectively, Fig 3B and 3C ).
marginally significantP = 0.05748921.1× alphagold
Hence, using two-factor repeated-measures ANOVA across time, the lower Mtb load in co-cultured macrophages as well as macrophages co-cultured with LAG-3 silenced blood-derived T-cells, was marginally significant ( P = 0.0574892) relative to infected macrophages ( P <0.01) at 96h ( Fig 3A ).
The majority of study participants who progressed to this combined endpoint met the CD4 criterion (15 versus 17 for prednisolone and placebo, respectively), whereas only a much smaller fraction of study participants reached the clinical endpoint “onset of AIDS-defining condition” (4 versus 11), and differences in this purely clinical endpoint did not quite reach statistical significance (p = 0.0575).
approached significancep = 0.0581.2× alpha
The same analysis in the group of 13 paired TD children showed that the effect of Speech Rate only approached significance, Χ 2 (2) = 5.69, p = 0.058 ( Fig 2 ), mainly reflecting a trend towards higher sensitivity in the normal rate condition ( d ′ = 1.85, SE 0.24) than in the natural fast rate condition ( d ′ = 1.49, SE .17; V = 71.00, p = .080 as shown by the Wilcoxon test).
showed a trendp = 0.0581.2× alpha
Restricting the analyses to participants without risky alcohol consumption (< 8 on AUDIT) (patients = 103, 48% men, mean age = 40.9 years; controls = 46, 50% men, mean age 40.5 years) showed a trend to lower DHEA-s levels in the patient group than in controls (p = 0.058), but otherwise the same results, thus, lower DHEA-s in patients only in the youngest age-group when analyzing age groups separately (data not shown).
nearly significantp = 0.0581.2× alphagold
Pearson’s correlations revealed no significant relationships between average weekly caffeine consumption, Day 2 performance variability learning magnitudes and performance variability retention magnitudes (p>0.190 for all), but there was a nearly significant positive relationship between average weekly caffeine consumption and Day 1 performance variability learning magnitudes ( Fig 3B , r = 0.3760, p = 0.058).
showed a trendp = 0.0581.2× alpha
Functional outcomes and weight loss measurements When compared to the vehicle, the R18D treatment group showed a significantly improved neurological score ( p = 0.02), while the R18 treatment group showed a trend to improvement in neurological score ( p = 0.058; Fig 2A ).
approached significancep = .0581.2× alpha
The correlation between the CFMT-novel and SIAS was significant when these individuals were removed (τ B = −.146, p = .017; ρ = −.212, p = .014; for sqrt-SIAS, r = −.195, p = .025, n = 133), and that between CFMT-total and SIAS approached significance (τ B = −.114, p = .058; ρ = −.167, p = .054; for sqrt-SIAS, r = −.216, p = .012, n = 133).