Barely Significant

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highly significantP-value < 0.051.0× alphaqualifiedgold
We found many bacterial species that exhibited highly significant correlations to these traits ( Fig 5A–5C , 967, 720, 1,056 bacteria out of the top 1,345 occurring bacteria had significant Spearman correlation, P-value < 0.05 after FDR correction for age, HbA1C% and BMI respectively, S12–S17 Tables in S2 File ).
a negative trendp<0.051.0× alphagold
Of the brain regions that loaded positively on the first principal component ( Figure 2B ), on the other hand, ratings of Suffering were significantly correlated with activity in the left anterior thalamus (r = 0.33) and DMPFC (r = 0.38), and showed a positive trend in the right anterior thalamus (r = 0.22, p<0.05); none of these brain regions were positively correlated with Pain, but the DMPFC showed a negative trend with ratings of Pain (r = −0.22, p<0.05).
a positive trendp<0.051.0× alphagold
Of the brain regions that loaded negatively on the first principal component ( Figure 2A ), ratings of Pain positively correlated with brain activity in left insula (pearson's r = 0.44, p<0.002), right insula (r = 0.43) and AMCC (r = 0.47), and showed a positive trend in lSII (r = 0.26, p<0.05) and rSII (r = 0.25, p<0.05); none of these brain regions were positively correlated with Suffering.
borderline non-significantp = 0.051.0× alpha
An association was observed with male gender (OR = 2.37; 95%CI 1.07–5.25; p = 0.03), older age which is borderline non-significant for the group 35–44 years (OR = 2.41; 95%CI 0.99–5.88; p = 0.05) and significant for the group 45–60 years (OR = 3.17; 95%CI 1.18–8.50; p = 0.02) and smoking (OR = 3.35; 95%CI 1.17–9.60; p = 0.02).