Excerpts

However, broad measures of cognitive function may only detect highly significant nutritional effects, especially if the study is underpowered [ 138 ].

Marginally statistically significant results should be interpreted with caution.

The results (data not shown) indicated a nonsignificant trend toward a very slight (<1.5-fold) upregulation of LCE3A , LCE3D , and LCE3E mRNA expression.

In vitamin C (100 μM)- treated samples, we found that miR-29b ( p = 0.04) and miR-4705 ( p = 0.04) were significantly down-regulated and miR-3942 ( p = 0.01) and miR-3152 ( p = 0.04) were significantly up-regulated whereas miRNA-371b showed a trend of up-regulation similar to our array findings.

t -tests demonstrate that there are highly significant positive information effects in all five cases.

After analysing the count of other bacteria groups, a constant quantity in Clept was observed in the experimental group supplemented with Synergy 1, whereas a decreasing trend was observed in the placebo group.

When analyzing the weight variation, a slight trend toward a greater weight gain was seen in the DS experimental groups in comparison to the corresponding DR groups, without reaching significance.

Indirect Dietary Contributions We observed a significant trend for a decreased intake in dietary fiber and plant-based protein paralleled by a higher intake of animal-based protein with an increasing habitual dietary pattern score.

We were aware from our earlier long-term DH studies that the age at diagnosis had increased significantly from 1970 onwards [ 1 ], and further, that there was a significant trend towards milder villous atrophy [ 16 ].

Contrary to PC, the level of lysophosphatidylcholine (LPC) showed a trend to be decreased in both the NAFL and NASH groups, without reaching significance ( Figure 1 D).

Vegetable intake (10 oz) was shown to be a significant parameter in the GR LOO model, whereas the interaction of MTHFR 677 with overweight BMI) was approaching significance with a p value of 0.059.

Moreover, a fairly significant correlation has been found between oxidative DNA damage in the human trabecular meshwork (HTM) and increased intraocular pressure and visual field defects in glaucoma patients [ 37 ].

Here we have shown improved episodic memory performance in delayed word recognition and marginally significant improved visuo-spatial Corsi Block performance at 3, but not 6, months following intervention alongside a lowering of systolic blood pressure at both time points.

Though our visuo-spatial findings here did not quite reach significance, beneficial effects of blueberry supplementation on visuo-spatial memory in aging rats is well documented (for example [ 9 , 25 ]), and polyphenol-rich chronic interventions with procyanidins have previously shown positive visuo-spatial benefits for older adults [ 26 , 27 ].

Additionally, the number of total newborns and live newborns showed an increasing trend in the daidzein group.

There was a decreasing trend in both SIRT1 and PPAR-α expression levels in the IDH2 FRU mice compared to the other groups, which is also in agreement with phenotypes (i.e., Figure 1 E).

Following two weeks intervention, the change from baseline of the global score in the 8 g/day dose polydextrose group compared to the placebo showed a numerical trend towards improvement, which after 4-weeks intervention was significantly different ( Table 3 ).

BMI was a significant or marginally significant covariate for several outcome variables.

[ 20 ], in their review of the influence of price changes through taxes and subsidies on demand and body weight outcomes, noted that, in comparison to previous reviews, they found a larger proportion of longitudinal versus cross-sectional and modeling studies, indicating a positive trend toward the use of prospective research designs.

The HO-diet provided more B12 to the liver than the CN-diet, and a strong trend to the higher accumulation of CN-B12 in the kidney as compared with HO-B12 was observed.

There is an increasing trend in prenatal cannabis use, due to the conception of need of cannabis for medical use, cannabis harmlessness, and increased access to this drug [ 6 ].

However, the risk allele (G) of variant rs1177681 was shown to be at a borderline level of statistical significance for overweight/obesity (OR = 1.42; 95% CI = 1.00–2.00).

reported highly significant heritability estimates of α-carotene and β-carotene in children [ 21 ].

The genetic heritability of α-carotene and β-carotene were barely significant, but lutein and lycopene still had highly significant genetic effects.

The aMed Score and Cognitive Function There was a significant trend for higher baseline MMSE and at higher tertiles of the aMed score in both base and full models.