Barely Significant

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a positive trendp = 0.1192.4× alphagold
However, there was a positive trend between diastolic BP at the third assessment and rGMV change in proximity to the right precuneus and postcentral gyrus (x, y, z = 18, −42, 63; (t = 4.09 and p = 0.119 corrected for FDR at the peak voxel); 4509 mm 3 at the threshold of uncorrected p < 0.001) ( Figure 4 ).
Publication bias assessment revealed minimal evidence of selective reporting bias: Egger’s regression test approached but did not reach significance (coefficient = 0.54, 95% CI: −0.18 to 1.26, p = 0.128), Begg’s test showed modest asymmetry (tau = 0.08, p = 0.052), trim-and-fill analysis identified only 2 potentially missing studies with minimal effect on pooled estimates, and universal concordance of all 30 fat oxidation studies (100% showing increased rates with 18 p < 0.001) demonstrates absence of selective reporting for this outcome.
a strong trendp = 0.153.0× alphagold
Furthermore, the HDIVC group had a strong trend towards more ventilator-free days (13.1 in the HDIVC group vs 10.6 in the placebo group mean difference, 2.47, 95% CI −0.90–5.85, p = 0.15), ICU-free days to day 28 (10.7 in HDIVC group vs. 7.7, in the placebo group, p = 0.03), and more hospital-free days (22.6 in HDIVC group vs. 15.5, respectively, p = 0.04).
approaching significancep = 0.193.8× alphagold
Significant associations were observed regarding the intake of individual carotenoids, including β-carotene (τ = 0.39, p = 0.0003), zeaxanthin, and lutein ( ρ = 0.58, p = 0.0001), apart from lycopene (τ = −0.09, p = 0.40) and α-carotene, which was approaching significance (τ = 0.14, p = 0.19).