Barely Significant

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Other components of the methionine cycle were also altered, with prenatal choline resulting in an increase in methionine in both males and females ( Supplemental Figure S7A,E ), an increase in B6 in males only ( Supplemental Figure S7B,F ), and an increase in Hcy ( Supplemental Figure S7C,G ), although in male plasma this did not quite reach statistical significance ( p = 0.06).
showed a trendp = 0.061.2× alpha
In response to conventional vitamin D therapy, participants who remained vitamin D deficient showed a trend towards an increased LF:HF ( p = 0.06), an increase not observed in subjects who achieved vitamin D levels within the insufficient and sufficient ranges ( p < 0.001 vs. deficient vitamin D group) ( Appendix Table A1 , Figure 3 ).