Barely Significant

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HFD also determined a significant increase in the weight of white adipose tissue and a significative reduction in brown adipose tissue weight, and the supplementation with CEVOO showed a trend, even if not significative, in improving these parameters, while CrOO ameliorated only the weight of the brown adipose tissue ( Figure 2 ).
A nonsignificant trend toward a U-shaped relationship between the UIC and the risk of developing TPOAb positivity was observed ( p overall < 0.001; p nonlinear = 0.085; Figure 2 A), with the lowest TPOAb positivity risk observed for participants with a UIC of 121.02 μg/L.
Although the results were marginally significant, there exists a potential association with LMM, suggesting that the nutritional imbalance resulting from a diet characterized by a reduced intake of protein-based foods, alongside increased consumption of refined carbohydrates, high glycemic index foods, and saturated fats, may contribute to the decline in muscle health.