Excerpts

For AD-related pathologies of amyloid plaques and Braak stage, e2 had large and highly significant protective effects contrasted with e3/e3 and e4 carriers with odds ratios of about 0.50 for e3 contrasts and 0.10 for e4 contrasts.

Subject terms: Atmospheric science, Atmospheric dynamics, Palaeoclimate Proxy reconstructions show a decreasing trend from the Middle to Late Holocene, which conflicts with model results showing an increasing trend.

In line with this and the results in the TZH cohort, the 60 hypomethylated gsSMK-CpGs exhibited a clear trend toward hypomethylation in smokers in the Liu, Hannum, and Tsaprouni cohorts, which was only consistent and much stronger in myeloid cells (Fig. 2b–d ).

These analyses confirmed that the 53 gsSMK-CpGs exhibited highly significant trends toward hypomethylation in smokers in both lineages, but more strongly so in myeloid cells (Fig. 1e, f ).

As the p value of BMP7 is close to significance in the multivariate model, we searched in The Gene Expression Omnibus (GEO) database for a second cohort of lung adenocarcinoma patients to have at least 100 patients.

An increasing trend was observed in + /del52 mice while + /ins5 was very similar to controls.

The GO term “metabolism” is highly significant in the downregulated gene set (Supplementary Fig. 3b and Supplementary Data 3 ), with fatty acid metabolism, flavonoid-related processes, and transmembrane transport GO terms statistically enriched.

NonCS port-entries were unaffected by CNO and showed a trend towards elevation in the alcohol context compared to the neutral context (Supplementary Fig. 6c ).

Consequently, we also consider effects that reach significance at alpha = 0.10 as marginally significant.

Log2 fold-change estimates of H3K27ac peaks overlapping the promoter of DEG showed a weak trend consistent with expression changes (Fig. 4b , upper panel).

The political costs of such curtailments may be significant, but so will be the costs of inaction.

After conducting GWAS on the 4505 isolates with associated azithromycin MICs, we identified highly significant unitigs (i.e., genetic variants generated from de novo assemblies) mapping to the 23S rRNA, associated with increased resistance, and to the efflux pump gene mtrC , associated with increased susceptibility and cervical infections 7 .

RNA recovery within the whole droplet showed an increasing trend as the water was lost from the coacervate mixture (Fig. 3e ).

For example, the combination of ruxolitinib with capecitabine showed a trend of improved survival in patients with metastatic pancreatic cancer and evidence of systemic inflammation 92 .

This was highly significant when compared to the overlap of randomized gene sets of the same number as the number of MPP8-repressed genes (Fig. 5d ).

Within the ATX group, we observed a positive trend between the pupil dilation response and the neural spread of association in parahippocampus-hippocampus (Fig. 6f ).

Patients with high tumor SMARCA2 (BRM) protein expression showed a trend towards a better overall survival, although this relationship did not reach statistical significance.

Thus, the aforementioned existence of signature metabolites for each group of tea accessions collected from diverse locations and environments is quite significant, as it suggests that these signature metabolites are predominantly determined by genetic factors.

qRT-PCR analysis confirmed the very large, highly significant increase in Gm15441 expression and its complete inhibition in Ppara −/− liver (Fig. 2c ).

This trend had marginal significance, changing with different parameters used for analysis.

Remarkably, we found a highly significant enrichment of the differentially expressed genes in GLP cKO (Fig. 5i ) and G9a cKO (Supplementary Fig.

The bird-only and mammal-only models also supported the findings, although the relationship between pace of life and migratory strategy was only marginally significant for mammals; this weaker association in mammals was likely driven by swimmers (see above, Supporting Information S4 ).

After a 5-min SP test, however, we observed a significant (or almost significant) increase of c-Fos induction specifically in the MeA and NAc shell, but not in the LSD, LSV, or NAc core (Supplementary Fig. 8 ; one-way ANOVA, LSV— F 2,12 = 0.847, p = 0.453; LSD— F 2,12 = 2.327, p = 0.140; NAc core— F 2,12 = 0.444, p = 0.652; NAc shell— F 2,12 = 3.767, p = 0.057; MeA— F 2,12 = 7.161, p = 0.009).

A ISW1a-dinucleosome model was constructed based on these data, but has not been validated during the last nine years, even though it would be highly significant as thus far no other ATP-dependent chromatin remodeler is known to act specifically on dinucleosomes.

Indeed, the pronounced focal accumulation of UHRF1-GFP observed in Dppa3KO and T12CM ESCs corresponded with a highly significant increase in the CV values of nuclear UHRF1-GFP compared with wt ESCs (Supplementary Fig. 4i, j ).