Analysis of the frequencies of mDCs and non-classical monocytes in the PLN showed a trend ( p = 0.08, Spearman's rank) toward correlating with higher levels of viral loads in this tissue, but fell short of statistical significance (Fig. 4d ).
While the combination therapy did not reach statistical significance over chemotherapy alone, a clear trend toward improved response was observed (Cis vs Combo, p = 0.08), mirroring clinical observations in advanced NSCLC patients 85 , 86 .
The amount of overlap in the top n genes was statistically significantly higher than expected for three species pairs, and marginally non-significant ( p < 0.08) for an additional two species pairs, such that we found some evidence of non-random overlap for 5/6 species pairs (Supplementary Table 9 ).
Consistently, HPLC determination of 5-HT levels in spinal cord extracts showed a trend toward higher caudal-to-rostral 5-HT concentrations in bPAC animals compared to control (0.51 ± 0.27vs.0.14 ± 0.11 μM/mg protein, respectively; p = 0.08, Mann–Whitney test, Fig. 5G ).
Comparison of each FEF condition relative to baseline (sham) showed that the sham condition provided a baseline between left and right FEF TUS effects, whereby left FEF TUS increased the proportion of rightward saccades ( b = −0.12, p = 0.023), and right FEF showed a trend toward more leftward saccades ( b = 0.12, p = 0.08).
Mutations in PIK3CA and MAP3K1 were significantly more likely to co-occur (after BH FDR correction) in the TAM dataset, and were near significance in MA12 although not after correction ( p = 0.08).
These profound individual changes were, however, masked by remarkable within-state variation among the other subjects so that the average group-level fold change following the intervention was moderate and only borderline significant (log 10 FC=−0.39; P =0.08; paired Wilcoxon test).
The WMH wGRS was not associated with the Stroop test in i-Share but showed a trend towards an association with poorer episodic memory performance in older community persons (N = 24,597, effect estimate ± SE: -0.19 ± 0.11, P = 0.08) 34 .
When predictive and nonpredictive events were separately compared across delay conditions, speeded RT over time for predictive actions was marginally significant ( t (23) = 1.85, p = 0.08), while slower RT over time for nonpredictive actions was not significant ( t (23) = 1.57, p = 0.13).
As compared to control mice given only an HFD, oral administration of spermidine significantly increased spermidine levels in WAT, with an increasing trend observed for L . reuteri ZJ617 ( P = 0.08).
In addition, at day 56, there was a statistically significant increase in cholesterol efflux capacity in SLE subjects treated with tofacitinib ( P = 0.002, 95% CI: 0.04–0.16) and a nonsignificant trend when compared to placebo ( P = 0.08, 95% CI: −0.01, 0.24) (Supplementary Fig. 5e ).
Of the remaining three species, the increase in mortality outside the native range was nearly significant for one ( p = 0.08) and non-significant, but still apparent, for two species moved from the warmest site to cooler, wetter sites (Fig.
We then stratified the analysis of TMB across the eligible tumor types and found significant associations with ICB response in melanoma and NSCLC (melanoma: 1.5-fold, Welch’s two-tailed t test p = 2.0 × 10 −5 ; NSCLC: 2.5-fold, p = 0.003) and a positive trend amongst bladder and head and neck tumors (bladder: 1.9-fold, Welch’s two-tailed t test p = 0.08; head and neck: 1.1-fold, p = 0.94) (Fig. 1e ).
A decreasing trend with age was similarly seen for FDG BBB PS in white matter and cerebellum but associations only approached significance ( P = 0.08 and P = 0.05, respectively).
In another model of human disease, we found significantly higher levels of Thbs1 mRNA and a strong trend ( P =0.08) towards higher levels of TSP-1 protein in whole-lung lysates from newborn calves with chronic hypoxia-induced PH ( Fig. 5d and Supplementary Fig. 27 ).
Spearman correlation coefficients ranged from −0.9 to −1, although with borderline significance (all P = 0.08) likely due to limited sample size.
Regression analysis showed that there was a marginally significant interaction between total life events and percent time spent in institutions on externalizing problems at age 16, B = 0.003, 95% CI [0.00, 0.01], β = 0.18, p = 0.08, and a significant interaction between the number of independent events and percent time in institutions on externalizing problems, B = 0.006, 95% CI [0.001, 0.01], β = 0.25, p = 0.01.
Correlations between changes in caudate/putamen DAT binding and PDRP expression were of borderline significance ( p = 0.08 for both regions); those with changes in PDCP expression were not significant ( p > 0.13; Bland-Altman correlations).
Interestingly, while none of the individual genes from the signature reached statistical significance when stroma surrounding benign glands in the prostates bearing high-Gleason and low-Gleason cancers was compared (sB.high-sB.low), the difference in ssGSEA scores for this comparison was marginally significant (Fig. 4b ; t -test, P = 0.08).
Examination of lung fibroblasts from Col1a1-CreERT2;Fas −/− mice also revealed an increase in senescence score trending towards significance ( p = 0.08) (Fig. 7b ) and a Bcl-2 :senescence gene Pearson correlation of 29% ( p < 0.05) (Fig. 7c , Supplementary Table 7 ).
This association was marginally significant for caregiver report ( p = 0.08).
The R3 subclass showed a weak trend toward NBNC (negative for HBV and HCV; 25% vs 16%; p = 0.081 by Fisher’s exact test).
We found a significant association between the neurochemical profiles observed for ketamine and autism in ABIDE2 ( r (14) = 0.563, p = 0.023, 95% CI [0.094, 0.828]) and a trend towards significance for ABIDE1 ( r (14) = 0.448, p = 0.081, 95% CI [−0.061, 0.772]) (Fig. 2B ).
While the subperiod-average percentage of the population >65 years only appeared as a marginally significant predictor (likelihood ratio test, p = 0.081) in the second-stage meta-regression (Supplementary Table 3 ), it is still conceivable that our estimates of the climate-change attributable death burden in Germany are biased by ignoring age-group-specific temperature-mortality associations.
The interaction between instruction and memory showed a trend (F(1,15) = 3.48, p = 0.082), pointing towards slightly more pronounced reaction time differences for TBR than TBF items.