Excerpts

Recent evidence suggests that the high-elevation environments of China have experienced an increasing trend of reactive N deposition, which is different from the decreasing temporal trend from cropland/city sites at lower elevations 24 .

For RFS, there is a weak trend favoring the Cy-pretreated participants (HR 0.79, 95% CI, 0.52 to 1.19, Supplementary Fig. 1B ).

We also ran multivariable analysis for RFS excluding arm, and no covariates were significant, but age, sex, and advanced disease status approached significance (Supplementary Table 6 ).

In contrast, the infiltration level and predictive role of RSPO1 + fibroblasts in predicting patient prognosis showed a trend opposite to that of POSTN + fibroblasts.

We found an overall trend of elevated Treg infiltration with decreasing Th17, CD4_Tem, and CD8_Tem proportions during HNSCC progression, which indicated the transition from an immune-activated TME to an immune-exhausted TME.

As an overall trend, mutant alleles accumulated progressively in the Maternal-F lineage until virtually no WT alleles remained, while in Paternal-F lineage, even at the endpoint of adulthood, approximately 60% of WT alleles persisted, in line with our single time point experiments (Fig. 4a, d , Supplementary Fig.

As expected, there was a larger number of trials (8/75) that had an insignificant (7/75) or marginally significant (1/75, whether it is significant depends on not correcting for multiple tests) sex comparison relegated to the supplementary information; hence, Trialtrove curators missed the sex comparisons in those 8/75 publications.

Statistically significant main effects were subject to Tukey’s highly significant difference (HSD) multiple comparison procedures to assess differences between factor levels.

Our previous study of mosquito delivery of ZIKV to mice found a highly significant increase in neutralizing antibody titer with increasing virus dose estimated via forced salivations 56 .

Electronic and coordination structure analysis The oxygen vacancy concentration in Ru/TiO 2 , Ru/Ti 4 O 7 , and Ru/TiO shows an increasing trend due to the different stoichiometric ratios of Ti and O (Fig. 3a ).

Since the O w ions are adsorbed on Ca ions, the O w -H ab bonds exhibit an increasing trend that is similar to the Ca-O w bonds.

Additionally, the refractive index of the pV4D4 films showed an increasing trend as the monomer-to-initiator flow ratios decreased (Supplementary Fig. 15c ).

Accordingly, ELISPOT showed a trend towards reduced number of NP8 reacting IgG1 secreting LLPCs in CK bone marrow (Supplementary Fig. 4i, j ).

To investigate whether the wrinkled surface phenotype of ws fruits is caused by the accumulation of phytotoxic SGAs compounds, we assessed SGAs content in fruit extracts by UPLC-MS revealing highly significant changes in γ-tomatine compared to other metabolites (Fig. 1e , Supplementary Fig. 3a–f ; Supplementary Data 5 ).

Specific expression of unc-23 cDNA in epithelia, or the epithelial-expression of mouse BAG2, but not unc-23 expression in CEPsh glia or muscle, results in highly significant rescue of the CEPsh glia defects in unc-23 mutants (Fig. 4e ).

Therefore, compared with previous studies that have achieved polymers with long-lived RTPs by crystal engineering or mix doping, realization of intrinsic polymers with full-color RTPs simply via one-pot preparation is highly significant.

Moreover, the goblet cell, and EEC related gene sets also showed a trend toward reduction (Fig. 2d ).

We found a clear trend in phylogenetic signal for the UC chromosomes compared to the ENAA chromosomes (Supplementary Fig. 16 ).

Pairwise differences in exposure across low, medium, and high provisioning areas were highly significant in all cases (Supplementary Table 2 ).

Most recorded locations showed a trend for a stronger single-pulse EP compared to steady-state EP, in contrast to the prediction of the superposition hypothesis.

5b ) showed a trend for S0 children to have higher responses than S1 children, especially for IgG, IgG1, and IgG3, which were increased by vaccination.

While the effect sizes estimated are barely significant, power analysis identifies only 22% power to identify a significant effect for hospitalization and 75% power to find an effect for death.

Although the oePCs showed a decreasing trend in DI values, they remained significantly higher than those of the cPCs, suggesting that oePCs were capable of maintaining their ability to differentially encode investigatory intentions across multiple days.

Although these findings clearly show an overall trend to improvement over prolonged follow-up, it should be noted that these improvements were not seen in everyone and QoL did remain somewhat lower in the LC than MC, even though not statistically so.

Many of the DHFR mutations with positive epistasis to Q33S were near-neutral in the WT context, and displayed small improvements in growth rate that were highly significant due to the low experimental error for the best-growing mutations (Fig. 4c ).