Excerpts

Thus, tools to aid in the early differential diagnosis of MSA would comprise a highly significant advance. α-syn-containing deposits are the histopathologic hallmark of synucleinopathies, but α-syn accumulation is nonetheless heterogeneous in different diseases in terms of its distribution, conformation and seeding capacity.

These differences in within-year-location prediction correlations between the random effects and SNP + EC models were highly significant for 10F-CV.

Of the 59,070 variant-lipid associations, 8238 reached the marginal significance threshold of P < 0.05/85/68 = 8.650519e-6 corrected for the 85 GWS loci and the 68 PCs that together explained 90% of the phenotypic variance.

Hepatic ketogenesis intermediates Aceto-Acetyl-CoA and HMG-CoA showed a nonsignificant trend toward lower expression in Fbxw7-null livers (Supplementary Fig. 6k ), likely because they are also involved in the mevalonate pathway.

1 predicts a decreasing trend for the density of charged species in the afterglow with increasing distance from the bulk plasma.

In addition to early tau markers, the more advanced stage marker pThr231-tau (antibody AT180) was also elevated, and the late stage marker pSer202/Thr205-tau (antibody AT8) showed an elevated trend in J20;GT (Supplementary Fig. 8b ).

REST overexpression had a highly significant effect on Aβ deposition in the hippocampus, reducing Aβ plaque burden by 63% (Fig. 9h, i ).

This might be significant as NGFR expression has been linked to invasive properties of melanoma cells 48 , 49 .

Although statistically barely significant, this could be attributed to a reduced opacity of the nightside atmosphere, i.e., the brightness temperature is determined by a lower atmospheric layer with slightly higher temperature.

In contrast, the association between rs4988235 and BMI remained weakly significant after adjustment for both genome-wide and locus-specific ancestry (Fig. 6C and Supplementary Data 8 ).

We also performed trajectory analyzes and observed a clear trend of early to late pseudotime along each R cell strand (Supplementary Fig. 6E ).

While we did not detect significant associations between metabolic parameters and melanoma antigen-specific T-cell responses, increased mitochondrial and FAO dependence showed a trend towards increased T-cell responses in CD8 and CD4 T cells respectively (Supplementary Fig. 3A ).

In keeping with this, patients with dominant OP histopathology showed a trend of being sampled furthest away from their first symptoms (Fig. 1c ), had longer periods of stay in hospital and were mechanically ventilated for longer (Supplementary Table 1 and Supplementary Fig. 3 ) (no statistical difference observed).

However, when adjusting for the top SNP (rs6914651) in the regression model, neither HLA-DPB1*03:01 or HLA-DPB1*04:01 were nominally significant, suggesting that it might not be a specific HLA-DPB1 allele that affects AU risk (supplementary Data 7 ).

Three additional genes exhibited borderline significant p values and represented results from extremely rare gene-burden masks that consider only variants appearing once in each cohort (singletons).

3 h–m) with significance or trend toward significance; these HSP47 gene expression changes were not observed in other tissues, including liver, heart, and pancreas tissue (Supplementary Fig. 4a –l).

While more patients experienced dostarlimab-related AEs (71%) than pembrolizumab-related AEs (57%), a numerical trend favoring dostarlimab was observed in the proportion of patients experiencing immune-related adverse events (irAEs) (31% for dostarlimab plus chemotherapy and 39% for pembrolizumab plus chemotherapy), serious adverse events (SAEs) (41% and 48%, respectively), AEs leading to treatment discontinuation (29% and 38%, respectively), and AEs leading to immunotherapy discontinuation (17% and 24%, respectively) (Table 5 ).

We investigated this by a simple and interpretable orthogonal analysis, calculating the number of cell lines crossing a nominally significant RRA < 0.05 for each drug (Fig. 2b and Supplementary Data Fig. 2e ) and for each cell line (Fig. 2c and Supplementary Data Fig. 2f ).

We used t-SNE 28 and UMAP 29 to cluster the data, revealing an interesting trend, with the data primarily clustered by cell line, rather than by drug or outgroup status (Fig. 2a ; Supplementary Data Fig. 2a–d ; UMAP parameters were selected using an automated Monte Carlo approach, see Methods).

The aspirin group, although only consisting of 8 genes, showed a nominally significant increase in connectivity compared to the full cyan module, suggesting it may be a useful modulator of cyan module expression.

Interestingly, the #3 mouse with HBsAg seroconversion showed a trend to have high IL-23, IFN-γ, IL12p70, IL-1β, IL-6, IL-17a and GM-CSF.

For the z-SDMs of Al-Al pairs, there is an obvious trend to be close to the signature of D0 3 -CSRO except zone 1.

Second, the whole lungs of JHU083-treated Mtb -infected mice showed a trend toward diminished glutamine pools while the cancer data showed an accumulation of glutamine in the tumor microenvironment as measured in excised syngeneic, solid tumors taken from the flank.

P -value less than 0.05 was statistically significant difference and P -value less than 0.01 was highly significant difference.

A decreasing trend was identified for AS and AC but not for ZC corals (Bayesian multiple regression model, R 2 = 0.89, Supplementary Fig. 6 ).