Barely Significant

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Forty-year mean occupancy was higher for species with an increasing trend (0.181, 95% CI: 0.172–0.191) than for species with a decreasing trend (0.128, 95% CI: 0.119–0.138; difference 0.0531, 95% CI: 0.0336–0.0711) (Fig. 2 ), showing that the distribution of more widespread species increased even more, whereas the distribution of narrow-ranged species became even more confined 31 , 38 .
Consistently with histological observations, we did not find any negative effect of Senp2 ablation on aldosterone levels, but rather a positive trend with an increase in 18-hydroxy-corticosterone plasmatic concentration in Senp2 cKO males at 24 weeks and a trend toward upregulation of Cyp11b2 expression in Senp2 cKO female adrenals at 4 weeks (Supplementary Fig.