Barely Significant

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For mBI, although the Friedman test indicated a significant temporal trend in the G-FMV group, post hoc pairwise comparisons did not reach statistical significance after Bonferroni correction (T0–T1: p = 0.031; T0–T2: p = 0.035; threshold p < 0.025).
a trend towards significancep = 0.0330.7× alpha
However, the Mann–Whitney U test comparing the biceps brachii group and the brachialis plus brachioradialis group on pronator teres toxin dose showed a trend towards significance ( p = 0.033, adjusted alpha = 0.0167), suggesting that patients in the biceps brachii group tended to receive a higher dose of pronator teres toxin.
marginally significantp = 0.0330.7× alphagold
A marginally significant time-dependent effect was observed for LDL-C ( p = 0.033 and p = 0.032, respectively); however, given the non-significant global test and the absence of meaningful effect modification, this single covariate deviation at the conventional threshold is unlikely to materially influence the robustness of our primary conclusions ( Supplementary Table S11 ).
nominally significantp = 0.0380.8× alphagold
Among diabetic patients, a nominally significant difference in unadjusted event rates was observed (12% vs. 35%, p = 0.038), though this exploratory subgroup analysis requires cautious interpretation given the small sample and absence of adjustment for confounders. 4.1.