Excerpts

However, this difference became borderline non-significant when men were stratified according to the presence or absence of benign prostatic hyperplasia (BPH).

In univariate analyses, age differences reached only borderline significance, with poorer outcomes observed mainly in individuals over 80 years.

Family history of LBP showed a trend towards increased risk (pooled OR 1.37, 95% CI 0.93–1.82) without reaching statistical significance.

The overall pooled prevalence across all regions was 57%, and subgroup tests demonstrated highly significant regional differences, implying that local environmental, ergonomic, or cultural factors likely modulate LBP risk.

Conclusions In this study, it was found that anti-HCV positive patients in our region showed a decreasing trend over a period of 15 years, the number of viremic patients decreased markedly after the widespread use of DAA treatments in 2016, and positive patients turned into an older population over the years.

Physicians’ previous experience with medicinal marijuana, perceived risks, and associated limitations may be significant factors influencing their willingness to prescribe marijuana for therapeutic purposes.

When inflammatory markers were added to the model, they showed a borderline significant association after adjustment.

A large-scale epidemiological study involving more than 3 million ICU admissions in the United States reported a CCI prevalence of approximately 34.4 per 100,000 people, with an increasing trend associated with advancing age.

The metabolic burden showed a trend toward association with a lower QoL, consistent with evidence that cardiometabolic changes emerge early during antipsychotic treatment in youth [ 15 ].

Conclusions: In this real-world prospective cohort, pioglitazone showed a trend toward increased SMM in unadjusted analysis that did not reach significance after adjustment, suggesting a hypothesis-generating signal warranting further investigation.

Although longitudinal studies with follow-up of up to 4 years suggest an overall trend toward clinical and functional improvement over time, a subgroup of patients remains with residual changes, including “fibrotic-like” changes, which underscores the importance of structured cardiopulmonary assessment in some hospitalized patients [ 3 , 4 ].

The elevated Cohen’s d values demonstrate that the magnitude of the observed difference between the groups is highly significant from a practical perspective. 4.

Coming back to the currently described study and given that the p -value was close to significance, the research indicated a potentially clinically meaningful, though statistically non-significant, advantage.

During the study period, a positive trend in the number of patient transfers was observed, particularly in 2018 (47.06%; Z = 1.39), and subsequently in 2019 (49.04%; Z = 2.22), 2021 (59.74%; Z = 3.90), and 2023 (57.75%; Z = 3.37) ( Figure 4 ).

Therefore, the results should be interpreted with caution, particularly for marginally significant associations. 3.

The variables “age” and “HPV 16/18” are at the limit of significance, with a p value of 0.061, indicating borderline significance.

In contrast, elevated Lp(a) levels showed a trend toward increased odds of lipid-rich plaque (OR 1.6, 95% CI 1.0–2.4) and thin-cap fibroatheroma (TCFA) (OR 1.5, 95% CI 0.9–2.5), although these associations did not consistently reach statistical significance across studies.

On multivariable Cox proportional hazards regression analysis, lymphovascular space invasion was the only significant prognostic factor for RFS, whereas pathological upstaging showed a nonsignificant trend ( Table 3 ).

Mean operative time showed a nonsignificant trend towards shorter procedures in 2023 (42 ± 24 min) compared with 46 ± 25 min in 2019.

Longitudinal analysis of surgical duration revealed only a weak trend rather than a demonstrable learning curve.

Heatmaps were generated using row-scaled (z-score) expression values for all nominally significant proteins ( n = 31) or the top 20 proteins ranked by raw p -value.

The incidence of premature infants with gestational age ≤ 25 weeks showed an increasing trend during the study, from four cases in the first year to 25 cases in the last year (2024) of the study.

This difference approached statistical significance (Fisher’s exact test, p = 0.050), suggesting a possible trend toward lower technical success in sleeve gastrectomy-related fistulas.

This study showed a trend towards increased risk in 30-day adverse events amongst patients who underwent GB; statistical significance was not achieved.

n = 2 ONT) suggested an increasing trend in the ONT samples ( Figure 6 D).