Barely Significant

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a nonsignificant trendp = 0.081.6× alphagold
If the cohorts were analyzed independently, the significances remained for the Lund cohort, but only mutational status, not histological type, correlated significantly to PD-L1 expression in the Halmstad cohort (in the Lund cohort, there was only a nonsignificant trend for lower PD-L1 in cytology than biopsies, p = 0.08). 2.3.
showed a trendp -value = 0.081.6× alpha
The inducer effect of calcium supplements on CACNA1C and ATP2C1 showed a trend to increase the expression of the FE genes (ES = 1.51, p -value = 0.08, and ES = 2.03, p -value = 2.23 × 10 −3 , respectively), which was not fully validated in the case of CACNA1C in the other datasets (ES = 1.25, p -value = 0.07, in GTEx; and ES = 1.66, p -value = 2.31 × 10 −3 , in CEDAR), nor validated in ATP2C1 (ES = 2.57, p -value = 1.04 × 10 −3 , in GTEx; and ES = −1.83, p -value = 0.01, in CEDAR).
borderline significantp = 0.08051.6× alphagold
The correlation was weak and borderline significant according to the Pearson correlation coefficient ( r P = −0.115, p = 0.0805), but significant according to the Spearman correlation coefficient ( r S = −0.157, p = 0.0163), possibly indicating a homeostatic effect of increased heterozygosity.