Excerpts

For the rs1800629 TNF-α polymorphism, the GA + AA genotypes showed a significant association ( p = 0.038) with the presence of unfavorable histology and were at the limit of significance ( p = 0.05) with high-risk category and INSS stage 4; however, there were no associations with other prognostic factors ( Table A1 ).

Nuclear MMP9 expression correlated with ACR and immune cell markers and was borderline significant for AMR ( p ≈ 0.05).

Among smaller, less precise studies toward the bottom of the plot, results were distributed across both significant (light gray area, p < 0.01) and marginally significant regions (dark gray area, 0.01 < p < 0.05), suggesting no evident directional bias.

The ratio of NP-positive HSCs of hydrophilic-NP-PBS treated liver was significantly higher compared with that of hydrophobic-NP-PBS treated liver and, also, almost significantly ( p = 0.05) higher compared with that of hydrophobic-NP-olive oil treated liver ( Figure 5 C).

A borderline significant positive association between MLR and AST was observed in the combined cohort (r = 0.188, p = 0.050).

p < 0.01 ** is considered to be extremely significant, p < 0.05 * is considered significant. 5.

There was also a weakly significant interaction of the factors antibody, sex and day (F 2,40 = 4.98, p < 0.05).

In addition, of the 154 candidate genes, 83 (54%, including NHLRC1 ) also had a nominally significant gene-wide p < 0.05 in at least one of the other three GWASs and/or the meta-analysis ( Table 1 ).

As a result, the HFS + STZ group showed a significant decrease in phosphorylation levels of Akt while the HFS group only showed a trend ( Figure 3 b, * p < 0.05, HFS + STZ vs.

The opposite was also observed in tolerance with an evident trend towards lower K/T ratios and higher STF levels in the tolerant recipients ( p < 0.05 by t -test).

This miRNA showed a differential expression only with a statistical trend ( p = 0.05) in our study, but had to be excluded from some statistical approaches due to its low expression levels. miR-183, which was better performing in our cohort than miR-96, also emerged as a possible marker for high-grade NMIBC in the report from Pardini et al., who identified promising diagnostic miRNAs by NGS in cell-free urine supernatants from BCa patients and control subjects [ 45 ].

While PPRH2 showed a trend toward greater single-agent activity, these differences were statistically significant only when comparing DOTAP to PPRH2 ( p < 0.05) and Sc9 to PPRH2 ( p < 0.01) ( Figure 3 A), indicating that this concentration was appropriately sub-cytotoxic for combination studies.

We detected 34 nominally significant differentially methylated regions (DMRs) ( p < 0.05, methylation difference > 10%), that included both hyper- and hypo-methylated loci ( Supplementary File S5 ) ( Figure 9 A).

The overall comparison among the three groups was highly significant (χ 2 = 10.78, df = 2, p < 0.05) ( Figure 5 B). 3.

The decrease in RPO-stimulated hippocampal theta power was highly significant ( p < 0.05; Student’s paired t -test, C1 vs.

The statistical analysis revealed a highly significant difference in the distribution of this type of cell between the two groups ( p < 0.05) [ 12 ]. 3.7.

Importantly, the fraction of necrotic cells remained low and did not reach statistical significance ( p < 0.05) under any of the tested conditions ( Supplementary Figures S1 and S2 ), indicating that RA-induced cell death was predominantly apoptotic.

Compared to the control groups, the miR-374b-5p mimic group showed a significant reduction in Vegfc mRNA expression ( Figure 1 E, p < 0.01), whereas the inhibitor group exhibited a nonsignificant trend toward increased Vegfc expression ( Figure 1 E, p > 0.05).

Although not statistically significant, Mitf mRNA levels displayed a decreasing trend in the mimic group relative to the other groups ( Figure 1 E, p > 0.05).

The FW-STI model exhibited a weaker fit ( R 2 = 0.54–0.70) with borderline significance (only W05 reached p < 0.05; p -values of 0.06–0.09 for the remaining samples).

Correlation analysis between co-expression modules and two traits (species and tissues) was carried out, and four highly significant active ingredients-related modules ( p -value < 0.05) were identified.

Consistently, from histological analyses of haematoxylin and eosin (H&E)-stained tibia sections, this study also observed an obvious trend of depletion of bone marrow cells following 4 cycles of AC treatment within the lower secondary spongiosa when compared to normal control rats ( p > 0.05) ( Figure 2 B–E).

FM groups, and the data from the two analyses showed a highly significant correlation ( p < 0.05).

As shown in Table 5 , a highly significant ( p < 0.05) correlation coefficient (0.85) was found between DPPH scavenging activity and TPC of the extracts, and the correlation coefficient between DPPH scavenging activity and TFC of the extracts was 0.674 ( p < 0.01).

Nominally significant associations ( p < 0.05) were observed for obesity, BMI, dementia, asthma, COPD/asthma-related infections, and serum urate ( Table S20 ).